Journal of Veterinary Science

  • 제23권2호
  • /
  • Pages.19.1-19.9
  • /
  • 2022
  • /
  • 1229-845X(pISSN)
  • /
  • 1976-555X(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
권호 표지
DOI QR코드

DOI QR Code

Prevalence and treatment of gastric ulcers in Thoroughbred racehorses of Korea

  • Hwang, Hyeshin (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University) ;
  • Dong, Hee-Jin (Department of Veterinary Pathobiology and Preventive Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University) ;
  • Han, Janet (College of Veterinary Medicine, Western University of Health Sciences) ;
  • Cho, Seongbeom (Department of Veterinary Pathobiology and Preventive Medicine, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University) ;
  • Kim, Yongbaek (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University) ;
  • Lee, Inhyung (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University)
  • 투고 : 2021.09.03
  • 심사 : 2021.12.07
  • 발행 : 2022.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Gastric ulcer is one of the prevalent diseases in racehorses. However, it has not been recognized as important in Korea, and drugs used to treat gastric ulcers are included in the doping test list, so they are not allowed to be administered to racehorses in training. Objectives: This study was performed 1) to investigate the prevalence and the severity of gastric ulcers in Thoroughbred racehorses in Korea, 2) to confirm the therapeutic effect of ranitidine and omeprazole, and 3) to compare the efficacy between ranitidine and omeprazole. Methods: Forty-nine horses were randomly recruited, and gastroscopy was performed within two days after racing. Twelve horses with a sum grade of five or higher were randomly assigned to two treatment groups. Seven horses were administered ranitidine, and five horses were administered omeprazole. Follow-up gastroscopy was scheduled within one to five days after finishing the treatment. Results: The prevalence of gastric ulcer in Korean Thoroughbred racehorses after racing was 100%, and the grade was more severe in the non-glandular region than in the pyloric region. There was no correlation between the severity of gastric ulcer in the two regions. Omeprazole had a greater therapeutic effect than ranitidine. Conclusions: This study shows the importance of recognizing gastric ulcers as an important factor, and omeprazole as a possible treatment option in Korea, as it has been removed from the list of prohibited substances for racehorses. Thus, the use of omeprazole is currently recommended until one day before the race.

키워드

과제정보

The authors would like to thank Abler Pharmaceuticals for their donation of omeprazole, Korea Racing Authority (KRA) for their financial support, and the trainers for their cooperation and assistance.

참고문헌

  1. Hackett ES. Specific causes of colic. In: Southwood LL, editor. Practical Guide to Equine Colic. 1st ed. Hoboken: Wiley-Blackwell; 2013, 205.
  2. Murray MJ. Diseases of the stomach. In: White NA, Moore JN, Mair TS, editors. The Equine Acute Abdomen. 2nd ed. Wyoming: Teton New Media; 2008, 577-582.
  3. Sanchez LC. Disorders of the gastrointestinal system. In: Reed SM, Bayly WM, Sellon DC, editors. Equine Internal Medicine. 3rd ed. Philadelphia: Saunders; 2009, 838-845.
  4. Videla R, Andrews FM. New perspectives in equine gastric ulcer syndrome. Vet Clin North Am Equine Pract. 2009;25(2):283-301. https://doi.org/10.1016/j.cveq.2009.04.013
  5. Begg LM, O'Sullivan CB. The prevalence and distribution of gastric ulceration in 345 racehorses. Aust Vet J. 2003;81(4):199-201. https://doi.org/10.1111/j.1751-0813.2003.tb11469.x
  6. Bell RJ, Mogg TD, Kingston JK. Equine gastric ulcer syndrome in adult horses: a review. N Z Vet J. 2007;55(1):1-12. https://doi.org/10.1080/00480169.2007.36728
  7. Luthersson N, Nielsen KH, Harris P, Parkin TD. The prevalence and anatomical distribution of equine gastric ulceration syndrome (EGUS) in 201 horses in Denmark. Equine Vet J. 2009;41(7):619-624. https://doi.org/10.2746/042516409X441910
  8. Endo Y, Tsuchiya T, Sato F, Murase H, Omura T, Korosue K, et al. Efficacy of omeprazole paste in the prevention of gastric ulcers in 2 years old Thoroughbreds. J Vet Med Sci. 2012;74(8):1079-1081. https://doi.org/10.1292/jvms.11-0545
  9. Lester GD, Smith RL, Robertson ID. Effects of treatment with omeprazole or ranitidine on gastric squamous ulceration in racing Thoroughbreds. J Am Vet Med Assoc. 2005;227(10):1636-1639. https://doi.org/10.2460/javma.2005.227.1636
  10. McClure SR, Carithers DS, Gross SJ, Murray MJ. Gastric ulcer development in horses in a simulated show or training environment. J Am Vet Med Assoc. 2005;227(5):775-777. https://doi.org/10.2460/javma.2005.227.775
  11. Orsini JA, Haddock M, Stine L, Sullivan EK, Rabuffo TS, Smith G. Odds of moderate or severe gastric ulceration in racehorses receiving antiulcer medications. J Am Vet Med Assoc. 2003;223(3):336-339. https://doi.org/10.2460/javma.2003.223.336
  12. White G, McClure SR, Sifferman R, Holste JE, Fleishman C, Murray MJ, et al. Effects of short-term light to heavy exercise on gastric ulcer development in horses and efficacy of omeprazole paste in preventing gastric ulceration. J Am Vet Med Assoc. 2007;230(11):1680-1682. https://doi.org/10.2460/javma.230.11.1680
  13. Loftin P, Cartmill JA, Andrews FM. Gastroscopy and esophagoscopy. In: Costa LRR, Paradis MR, editor. Manual of Clinical Procedures in the Horse. 1st ed. Hoboken: Wiley-Blackwell; 2017, 195-200.
  14. Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European college of equine internal medicine consensus statement--equine gastric ulcer syndrome in adult horses. J Vet Intern Med. 2015;29(5):1288-1299. https://doi.org/10.1111/jvim.13578
  15. Sykes BW, Jokisalo JM. Rethinking equine gastric ulcer syndrome: part 1-Terminology, clinical signs and diagnosis. Equine Vet Educ. 2014;26(10):543-547. https://doi.org/10.1111/eve.12236
  16. Murray MJ, Schusser GF, Pipers FS, Gross SJ. Factors associated with gastric lesions in thoroughbred racehorses. Equine Vet J. 1996;28(5):368-374. https://doi.org/10.1111/j.2042-3306.1996.tb03107.x
  17. Dionne RM, Vrins A, Doucet MY, Pare J. Gastric ulcers in standardbred racehorses: prevalence, lesion description, and risk factors. J Vet Intern Med. 2003;17(2):218-222. https://doi.org/10.1892/0891-6640(2003)017<0218:GUISRP>2.3.CO;2
  18. McClure SR, Glickman LT, Glickman NW. Prevalence of gastric ulcers in show horses. J Am Vet Med Assoc 1999;215(8):1130-1133.
  19. International Federation of Horseracing Authorities. Annual Report 2018. Boulogne: International Federation of Horseracing Authorities; 2018, p 36.
  20. Banse HE, Andrews FM. Equine glandular gastric disease: prevalence, impact and management strategies. Vet Med (Auckl). 2019;10:69-76.
  21. Lavoie JP, Hinchcliff KW. Blackwell's Five-Minute Veterinary Consult: Equine. Hoboken: Wiley-Blackwell; 2011, p 336-339.
  22. MacAllister CG. A review of medical treatment for peptic ulcer disease. Equine Vet J Suppl. 1999;31(29):45-49. https://doi.org/10.1111/j.2042-3306.1999.tb05168.x
  23. McClure SR, White GW, Sifferman RL, Bernard W, Doucet MY, Vrins A, et al. Efficacy of omeprazole paste for prevention of gastric ulcers in horses in race training. J Am Vet Med Assoc. 2005;226(10):1681-1684. https://doi.org/10.2460/javma.2005.226.1681
  24. Merritt AM, Sanchez LC, Burrow JA, Church M, Ludzia S. Effect of GastroGard and three compounded oral omeprazole preparations on 24 h intragastric pH in gastrically cannulated mature horses. Equine Vet J. 2003;35(7):691-695. https://doi.org/10.2746/042516403775696339
  25. Murray MJ, Haven ML, Eichorn ES, Zhang D, Eagleson J, Hickey GJ. Effects of omeprazole on healing of naturally-occurring gastric ulcers in Thoroughbred racehorses. Equine Vet J. 1997;29(6):425-429. https://doi.org/10.1111/j.2042-3306.1997.tb03153.x
  26. Sykes BW, Sykes KM, Hallowell GD. A comparison between pre- and post-exercise administration of omeprazole in the treatment of EGUS: a randomised, blinded clinical trial. Equine Vet J. 2014;46(4):422-426. https://doi.org/10.1111/evj.12083
  27. Sykes BW, Sykes KM, Hallowell GD. A comparison of three doses of omeprazole in the treatment of equine gastric ulcer syndrome: a blinded, randomised, dose-response clinical trial. Equine Vet J. 2015;47(3):285-290. https://doi.org/10.1111/evj.12287
  28. Sykes BW, Sykes KM, Hallowell GD. A comparison of two doses of omeprazole in the treatment of equine gastric ulcer syndrome: a blinded, randomised, clinical trial. Equine Vet J. 2014;46(4):416-421. https://doi.org/10.1111/evj.12191