Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Effects of Albizia julibrissin Durazz through Suppression of Mitochondrial Fission and Apoptosis in Cisplatin-induced Acute Kidney Injury

  • Hui-Ju, Lee (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) ;
  • Kyung-Hyun, Kim (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) ;
  • Yae-Ji, Kim (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) ;
  • Sung-Pil, Cho (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University) ;
  • Geum-Lan, Hong (Department of Anatomy, College of Medicine, Konyang University) ;
  • Ju-Young, Jung (Department of Veterinary Medicine & Institute of Veterinary Science, Chungnam National University)
  • Received : 2022.10.25
  • Accepted : 2022.12.14
  • Published : 2022.12.31
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Abstract

Albizia julibrissin Durazz. (AJ; family Minosaceae) is widely distributed worldwide, and its stem bark has been used as a traditional herbal medicine. Acute kidney injury (AKI) is a clinical syndrome that results in sudden loss of renal function. This study aimed to investigate the effects of AJ against cisplatin-induced AKI using a human kidney proximal tubule epithelial cell line (HK-2) and cisplatin-treated mice. In vitro, cisplatin treatment increased apoptosis in HK-2 cells. However, AJ treatment decreased apoptosis of cisplatin-treated HK-2 cells. In vivo, cisplatin treatment accelerated renal injury by increasing the levels of renal injury markers, such as blood urea nitrogen, creatinine, kidney injury molecule 1, and neutrophil gelatinase-associated lipocalin, which were reversed by AJ treatment. Histopathologically, AJ treatment resulted in decreased renal damage with less tubular necrosis and brush border desquamation compared with the AKI group. Additionally, cisplatin treatment upregulated mitochondrial fission, a pathological characteristic of AKI, which was downregulated by AJ treatment. Along with increased mitochondrial fission, AJ treatment also reduced cisplatin-induced apoptosis. These results suggest that AJ may be a potential therapeutic agent for cisplatin-induced AKI.

Keywords

Acknowledgement

This study was carried out with the support of 'R&D Program for Forest Science Technology (Project No. 2022421A00-2233-AA02) provided by Korea Forest Service (Korea Forestry Promotion Institute).

References

  1. Han, L.; Pan, G.; Wang, Y.; Song, X.; Gao, X.; Ma, B.; Kang, L. J. Pharm. Biomed. Anal. 2011, 55, 996-1009. https://doi.org/10.1016/j.jpba.2011.04.002
  2. Li, W.; Yang, H. J. Molecules 2020, 25, 2065. https://doi.org/10.3390/molecules25092065
  3. Chang, J. S.; Liu, H. P.; Cheng, J.; Chen, C. J.; Hwang, S. L.; Tseng, C. C.; Hsu, L. F.; Lin, W. Y. Evid. Based Complement. Alternat. Med. 2019, 2019, 7395962.
  4. Kokila, K.; Priyadharshini, S. D.; Sujatha, V. Int. J. Pharm. Pharm. Sci. 2013, 5, 70-73.
  5. Zheng, L.; Zheng, J.; Zhao, Y.; Wang, B.; Wu, L.; Liang, H. Bioorg. Med. Chem. Lett. 2006, 16, 2765-2768. https://doi.org/10.1016/j.bmcl.2006.02.009
  6. Kwon, S. H.; Hong, S. I.; Ma, S. X.; Lee, S. Y.; Jang, C. G. Food Chem. Toxicol. 2015, 80, 41-51.
  7. Gupta, A.; Mishra, A. K.; Bansal, P.; Kumar, S.; Sannd, R.; Gupta, V.; Goyal, B. M.; Singh, A. K.; Kumar, A. Drug Invent. Today 2010, 2, 191-193.
  8. Zuk, A.; Bonventre, J. V. Annu. Rev. Med. 2016, 67, 293-307. https://doi.org/10.1146/annurev-med-050214-013407
  9. Yuan, L.; Yuan, Y.; Liu, F.; Li, L.; Liu, J.; Chen, Y.; Cheng, J.; Lu, Y. Aging 2021, 13, 8421-8439. https://doi.org/10.18632/aging.202653
  10. McSweeney, K. R.; Gadanec, L. K.; Qaradakhi, T.; Ali, B. A.; Zulli, A.; Apostolopoulos, V. Cancers (Basel) 2021, 13, 1572. https://doi.org/10.3390/cancers13071572
  11. Kuhlmann, M. K.; Burkhardt, G.; Kohler, H. Nephrol. Dial. Transplant. 1997, 12, 2478-2480. https://doi.org/10.1093/ndt/12.12.2478
  12. Bhargava, P.; Schnellmann, R. G. Nat. Rev. Nephrol. 2017, 13, 629-646. https://doi.org/10.1038/nrneph.2017.107
  13. Kleele, T.; Rey, T.; Winter, J.; Zaganelli, S.; Mahecic, D.; Perreten Lambert, H.; Ruberto, F. P.; Nemir, M.; Wai, T.; Pedrazzini, T.; Manley, S. Nature 2021, 593, 435-439. https://doi.org/10.1038/s41586-021-03510-6
  14. Zhang, X.; Agborbesong, E.; Li, X. Int. J. Mol. Sci. 2021, 22, 11253. https://doi.org/10.3390/ijms222011253
  15. Wang, J.; Pabla, N.; Wang, C. Y.; Wang, W.; Schoenlein, P. V.; Dong, Z. Am. J. Physiol. Renal Physiol. 2006, 291, F1300-F1307. https://doi.org/10.1152/ajprenal.00509.2005
  16. Wang, Y.; Cai, J.; Tang, C.; Dong, Z. Cells 2020, 9, 338. https://doi.org/10.3390/cells9020338
  17. Rosner, M. H.; Perazella, M. A. Kidney Res. Clin. Pract. 2019, 38, 295-308.
  18. Hong, G. L.; Kim, H. T.; Park, S. R.; Lee, N. H.; Ryu, K. A.; Kim, T. W.; Song, G. Y.; Jung, J. Y. Nat. Prod. Sci. 2019, 25, 200-207. https://doi.org/10.20307/nps.2019.25.3.200
  19. Tanase, D. M.; Gosav, E. M.; Radu, S.; Costea, C. F.; Ciocoiu, M.; Carauleanu, A.; Lacatusu, C. M.; Floria, M.; Rezus, C. Int. J. Mol. Sci. 2019, 20, 5238. https://doi.org/10.3390/ijms20205238
  20. Tornblom, S.; Nisula, S.; Petaja, L.; Vaara, S. T.; Haapio, M.; Pesonen, E.; Pettile, V.; FINNAKI study group. Ann. Intensive Care 2020, 10, 51 https://doi.org/10.1186/s13613-020-00667-7
  21. Shaw, R. J.; Kosmatka, M.; Bardeesy, N.; Hurley, R. L.; Witters, L. A.; DePinho, R. A.; Cantley, L. C. Proc. Natl. Acad. Sci. U S A. 2004, 101, ,3329-3335. https://doi.org/10.1073/pnas.0308061100
  22. Toyama, E. Q.; Herzig, S.; Courchet, J.; Lewis, T. L. Jr.; Loson, O. C.; Hellberg, K.; Young, N. P.; Chen, H.; Polleux, F.; Chen, D. C.; Shaw, R. J. Science 2016, 351, 275-281. https://doi.org/10.1126/science.aab4138
  23. Morigi, M.; Perico, L.; Rota, C.; Longaretti, L.; Conti, S.; Rottoli, D.; Novelli, R.; Remuzzi, G.; Benigni, A. J. Clin. Invest. 2015, 125, 715-726. https://doi.org/10.1172/JCI77632
  24. Labbe, K.; Murley, A.; Nunnari, J. Annu. Rev. Cell Dev. Biol. 2014, 30, 357-391. https://doi.org/10.1146/annurev-cellbio-101011-155756
  25. Zhao, C.; Chen, Z.; Qi, J.; Duan, S.; Huang, Z.; Zhang, C.; Wu, L.; Zeng, M.; Zhang, B.; Wang, N.; Mao, H.; Zhang, A.; Xing, C.; Yuan, Y. Oncotarget 2017, 8, 20988-21000. https://doi.org/10.18632/oncotarget.15470