Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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A literature study of Huangqintang for standardization and KCD code

황금탕(黃芩湯) 표준화 및 KCD 질병코드 연구 - 동의보감 및 PUBMED를 중심으로

  • 박선빈 (동국대학교 한의과대학 방제학교실) ;
  • 염승희 (동국대학교 한의과대학 방제학교실) ;
  • 김수진 (동국대학교 한의과대학 방제학교실) ;
  • 한유정 (동국대학교 한의과대학 방제학교실) ;
  • 이지호 (동국대학교 한의과대학 방제학교실) ;
  • 김영우 (동국대학교 한의과대학 방제학교실) ;
  • 박선동 (동국대학교 한의과대학 방제학교실)
  • Received : 2021.10.01
  • Accepted : 2022.02.26
  • Published : 2022.02.28
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Abstract

Objectives : Huangqintang(⿈芩湯) is a famous herbal prescription in the Traditional Korean Medicine (e.g. Shanghanlun) to treat various chronic disease such as neurological disease and digestive system disease. Its components include Scutellariae Radix(⿈芩), Paeonia lactiflora(芍藥), Glycyrrhizae Radix et Rhizoma(⽢草), Zizyphi Fructus(⼤棗). Methods : In this study, we standardize the name, composition and medical uses of Huangqintang by literature studying and paper searching. Based on the comparison between oriental medicine and modern medicine pharmacology, we linked the medical uses of Huangqintang to Korean Standard Classification of Diseases (KCD). Results and Conclusion : The name of the prescription is unified into "Huangqintang", and its composition ratio between Scutellariae Radix, Paeonia lactiflora, Glycyrrhizae Radix et Rhizoma, and Zizyphi Fructus is 3:2:2:3. Huangqintang is used for enteritis diseases due to its antipyretic and antinflammatory effects. Its medical application was relatied with 'A'code, 'C'code, and 'K'code as indicated by KCD. By standardizing the mixed conceptions of Huangqintang, this review will facilitate the coding of Huangqintang prescription. Therefore, it will make Huangqintang prescription more useful in clinics.

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References

  1. Moon JJ, Ahn GS, Kim SH, Park JH, Kim DH, Choi DY et al. ShangHanLunJeongHae. 4th. Seoul:HanEuiMunHwaSa. 2019:354-356.
  2. Liu Duzhou. Proofreading ShangHanLun Dictionary. Seoul:EuiSeongDang. 1991:466.
  3. Yang Baifu Li Peisheng, Practical formula integration. Chinese People's Health Publishing House. 1996:63.
  4. Hwang Doyeon. Bangyakhappyeon with Pattern & Pulse. Seoul:NamSanDang. 1977:208.
  5. Choi Dalyoung. Interpretation & Lecture of ShangHanLun. Seoul:DaeSungMunHwaSa. 1995:282-284.
  6. Lu Zhijie. Ancient and Modern Application of Zhongjing's Medicinal Formula. 2nd. China:China Pharmaceutical Science and Technology Press. 2000:743.
  7. Shimada Y, Fujimoto M, Nogami T, Watari H. Adverse Events Associated with Ethical Kampo Formulations: Analysis of the Domestic Adverse-Event Data Reports of the Ministry of Health, Labor, and Welfare in Japan. Evidence-Based Complementary and Alternative Medicine. 2019:2019:1643804. https://doi.org/10.1155/2019/1643804
  8. Zhang Huihui, Yang Weipeng. Research on Anti-inflammatory Effect and Mechanism of Huangqin Decoction. China Academy of Chinese Medical Sciences. 2014.
  9. Kim SJ, Lee JB, Choi HM, Lee HY, Kim MJ, Lee MH, et al. Evaluation on Pharmacological Effects and Component Analysis of Hwanggeumjakyak-tang Formulation for Tablet. Korean Journal of Pharmacognosy. 2018:49(4):362-371.
  10. Heo Joon, DongEuiBoGam with Checkpoint & Index. Seoul:BubInMunHwaSa. 2005:368, 371, 526, 717-718, 1170.
  11. Changlin Z, Ying Z, Shuhua Z, Zeng J, Chi H. Research on the Protective Effect of MiR-185-3p Mediated by Huangqin-Tang Decoction (HQT) on the Epithelial Barrier Function of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2021:2021:4775606.
  12. Korean Pharmacopoeia and Herbal Medicine (Crude Medicine) Specifications. Ministry of Food and Drug Safety.
  13. Peng Huairen. Dictionary of Chinese Medicine Prescription. China:People's Health Publishing Co. 1986:120.
  14. Shin CH. Catechetical Herbal Formula Study. Seoul:SeongBoSa. 1992:112-113.
  15. Peng Huairen. Dictionary of Chinese Medicine Prescription. China:People's Health Publishing Co. 1986:120.
  16. Wang C, Tang X, Zhang L. Huangqin-Tang and Ingredients in Modulating the Pathogenesis of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2017:2017:7016468. https://doi.org/10.1155/2017/7016468
  17. Zhang BG, Liang XX, Liu QF. Modern pharmacodynamics research and clinic application of huangqintang. Zhongguo Zhong Yao Za Zhi. 2008:33(22):2587-2590.
  18. Ham IH, Maeng WM, Yang GS, Kim DH, Cho JH, et al. Study on the Variation of Components from Scutellariae Radix by Processing and Storage Condition. The Korea Journal of herbology. 2007:22(2):189-199.
  19. Herbal medicine explanation and medication guidance, Korean Pharmaceutical Association, 2006.
  20. Japanese pharmacopoeia. Japanese Pharmacopoeia 17th Edition.
  21. Kimata Y, Ogawa K, Okamoto H, Chino A, Namiki T. Efficacy of Japanese traditional(Kampo) medicine for treating chemotherapy-induced peripheral neuropathy: A retrospective case series study. World J Clin Cases. 2016:4(10)310-317. https://doi.org/10.12998/wjcc.v4.i10.310
  22. Chen P, Zhou X, Zhang L, et al. Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis. J Ethnopharmacol. 2015;162:207-214. https://doi.org/10.1016/j.jep.2014.12.039
  23. Yan MZ, Zuo F, Song HY, Ye WH, Zhou ZM. Comparative study on antibacterial effects of huangqin-tang and its metabolites produced by intestinal flora. Zhongguo Zhong Yao Za Zhi. 2003;28(3):243-246.
  24. Zou Y, Li WY, Wan Z, Li WY, Zhao B, Lu YJ, et al. Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4(+) T Cells. Biomed Res Int. 2015;2015:102021. https://doi.org/10.1155/2015/102021
  25. Hsu HY, Hsu CS: Commonly Used Chinese Herb Formulas - With Illustrations. Los Angeles: Oriental Healing Art Institute. 1980.
  26. Zou Y, Lin J, Li W, Wu Z, He Z, Huang G, et al. Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response. Sci Rep. 2016;6:39299. https://doi.org/10.1038/srep39299
  27. Liu Q, Zuo R, Wang K, Nong FF, Fu YJ, Huang SW, et al. Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-κB pathway. Acta Pharmacol Sin. 2020;41(6): 771-781. https://doi.org/10.1038/s41401-019-0335-4
  28. Wang YW, Zhang HH, Wang YL, Guo S, Li T, Chen L, et al. Effect of huangqin tang on the regulatory NF-κB p65 signal pathway in rats with ulcerative colitis. Yao Xue Xue Bao. 2015;50(1): 21-27.
  29. Wang DF, Wang YL, Wang YW, Guo S, Zhuang S, Xu H, et al. Effect of Huangqin Tang on the function of regulatory TLR4/MyD88 signal pathway in rats with ulcerative colitis. Yao Xue Xue Bao. 2016;51(10):1558-1563.
  30. Wang D, Shi K, Wang Y, Zou D, Guo S, Li T, et al. Effect of Huangqin Tang on Colonic Gene Expression in Rats with Ulcerative Colitis. Int J Genomics. 2020;2020:4238757.
  31. Zheng XB, Liu HB, Feng YL, Dai SX. Huangqin decoction lowers the number of mast cells in ulcerative colitis in rats with dampness and heat syndrome. Nan Fang Yi Ke Da Xue Xue Bao. 2011;31(2):252-255.
  32. Chen G, Yang Y, Hu C, Cheng X, Xu Y, Cai X, et al. Protective effects of Huangqin Decoction against ulcerative colitis and associated cancer in mice. Oncotarget. 2016;7(38):61643-61655. https://doi.org/10.18632/oncotarget.11426
  33. Chen D, Zhao J, Cong W. Chinese Herbal Medicines Facilitate the Control of Chemotherapy-Induced Side Effects in Colorectal Cancer: Progress and Perspective. Front Pharmacol. 2018;9:1442. https://doi.org/10.3389/fphar.2018.01442