한국섬유공학회지 (Textile Science and Engineering)

  • 제59권1호
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  • Pages.47-54
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  • 2022
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  • 1225-1089(pISSN)
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  • 2288-6419(eISSN)
한국섬유공학회 (The Korean Fiber Society)
권호 표지
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아세틸화 키토산 표면에서 의사체액에 의한 수산화인회석 결정의 생성

In-situ Crystalline Formation of Nano-hydroxyapatite Using Simulated Body Fluids on the Surface of Acetylated Chitosan

  • 김홍성 (부산대학교 바이오소재과학과)
  • Kim, Hong Sung (Department of Biomaterial Science, Pusan National University)
  • 투고 : 2022.01.24
  • 심사 : 2022.02.17
  • 발행 : 2022.02.28
⟨ 이전 논문 다음 논문 ⟩

초록

Hydroxyapatite/chitosan composites are being researched as useful biomaterials for bone repair and regeneration. In order to make a biomimetic composite, the in vitro formation of apatite on the surface of the acetylated chitosan film using a simulated body fluid was tested. The formation and in-situ crystallization behavior of hydroxyapatite as a function of the degree of acetylation was investigated. The surface of the acetylated chitosan was densely covered by forming a cluster of a plate-shaped crystalline phase with a thickness of approximately 20 nm, and the crystalline cluster was identified with apatite, including hydroxyapatite. The closer the acetylation rate of chitosan was to 50%, the larger were the amount of crystalline phases formed, and the Ca/P ratio gradually increased to reach 1.67 of hydroxyapatite. As the ratio of glucosamine and acetylglucosamine in chitosan became identical, the formation of apatite was maximized and hydroxyapatite accounted for most of them.

키워드

과제정보

이 과제는 부산대학교 기본연구지원사업(2년)에 의하여 연구되었음.

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