대한화장품학회지 (Journal of the Society of Cosmetic Scientists of Korea)

  • 제48권4호
  • /
  • Pages.313-319
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  • 2022
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  • 1226-2587(pISSN)
  • /
  • 2288-9507(eISSN)
대한화장품학회 (Society of Cosmetic Scientists of Korea)
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국내산 대마로부터 추출한 칸나비디올 함유 크림의 역가 및 안정성 평가

A Study on the Potency and Stability of the Cream Containing Cannabidiol Extracted Cannabis sativa L. from Korea

  • 유성동 (유한건강생활 건강생활연구소) ;
  • 김혜림 (유한건강생활 건강생활연구소) ;
  • 성기준 (유한건강생활 건강생활연구소) ;
  • 전정태 (유한건강생활 건강생활연구소) ;
  • 송애리 (유한건강생활 건강생활연구소) ;
  • 강종수 (유한건강생활 건강생활연구소) ;
  • 박일범 (유한건강생활 건강생활연구소)
  • 투고 : 2022.10.17
  • 심사 : 2022.12.09
  • 발행 : 2022.12.30
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초록

본 연구에서는 국내산 대마로부터 추출된 순도 99% 이상 칸나비디올(cannabidiol, CBD)을 1% 함유한 크림의 안정성을 평가하였다. 12 주간 온도별 저장조건(4 ℃, 25 ℃, 37 ℃, 45 ℃)에서 2 주 간격으로 pH, 경도, 함량, 색도를 측정하였다. CBD를 1% 함유한 실험군 의 pH는 대조군보다 더 감소하는 경향을 나타내었다. HPLC를 이용하여 온도별로 12 주 동안 실험군 내 CBD의 함량 변화를 확인한 결과, 온도에 따른 감소량의 차이를 확인하였다. 분광측색계를 이용하여 색차를 확인한 결과, 저장 기간 및 온도 증가에 따라 대조군에 비해 실험군 황색도가 증가함을 확인하였다. 이상의 결과로부터 pH 5 ~ 6의 실험군 제형의 온도에 따른 함량 감소 및 색상 변화를 확인하였다. CBD를 향후 의약품 및 화장품에 적용 시 온도에 따른 CBD의 역가 및 이화학적 품질변화를 고려한 연구개발이 수행되어야 할 것으로 판단된다.

In this study, the stability of cream containing 1% of cannabidiol (CBD) with more than 99% extracted from domestic Cannabis sativa was evaluated. The pH, hardness, content, and chromaticity were measured at intervals of 2 weeks under storage conditions for each temperature for 12 weeks (4 ℃, 25 ℃, 37 ℃, and 45 ℃). The pH of the experimental group containing 1% of CBD tended to decrease more than that of the control group. As a result of measuring the change in the content of CBD in the cream under each temperature for 12 weeks using HPLC, the difference in the amount of decrement according to temperature was confirmed. It was confirmed that as a result of measuring the chromaticity using color difference meter, the yellowness of the cream containing CBD increased according to the increase by the storage period and temperature compared to the control group. From the above results, it was confirmed that the content decrease and color change according to the temperature of the pH 5 ~ 6 cream formulation containing CBD. When CBD is applied to medicine and cosmetic formulations in the future, it is considered that research and development should be conducted in consideration of the change in the quantity and physicochemical quality of CBD under the temperature.

키워드

과제정보

본 연구는 중소벤처기업부의 규제자유특구혁신사업육성지원(과제번호 : P0016082)에 의한 연구임.

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