Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
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Dioscorea batatas Decne Glycoprotein Prevents Ecotoxicological Effects of Bisphenol A in Gastrointestinal Epithelial Cells and Improves Fecal Malodor and Feed Efficiency in Mice

환경호르몬 비스페놀 A가 유도한 위장관 세포독성 제어효과를 가진 마 당단백질이 마우스의 식이 효율 및 악취저감에 미치는 영향

  • Kim, Do-Wan (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Park, Moon-Ki (Department of Pharmaceutical Engineering, Daegu Haany University) ;
  • Kim, Tae Hoon (FoodyWorm Inc.) ;
  • Lee, Sei-Jung (Department of Pharmaceutical Engineering, Daegu Haany University)
  • 김도완 (대구한의대학교 제약공학과) ;
  • 박문기 (대구한의대학교 제약공학과) ;
  • 김태훈 ((주)푸디웜) ;
  • 이세중 (대구한의대학교 제약공학과)
  • Received : 2021.09.01
  • Accepted : 2021.12.07
  • Published : 2022.01.31
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Abstract

As a herbal supplement, Dioscorea batatas Decne (DBD) presents potent antioxidant activity and diverse health benefits. In the present study, functions of a 30 kDa glycoprotein isolated from DBD (hereafter, DBD glycoprotein) in the regulation of feed efficiency and fecal malodor in mice were explored. DBD glycoprotein produced protective effect against cytotoxicity induced by the ecotoxicological endocrine-disrupting substance bisphenol A in gastrointestinal epithelial HT-29 cells. To investigate its potential roles in the regulation of feed efficiency and fecal malodor, mice were administered an oral injection of DBD glycoprotein for 2 weeks. Compared with the control values, the weight of internal organs (liver, heart, kidney, and spleen) and levels of glutamate pyruvate transaminase, glutamate oxaloacetate transaminase, and lactic dehydrogenase were not significantly changed during DBD glycoprotein administration for 2 weeks. Interestingly, DBD glycoprotein improved feed efficiency and reduced hydrogen sulfide concentration without altering the ammonia level in mouse feces. Collectively, these results indicate that DBD glycoprotein is a functional agent that exerts gastrointestinal protective effects against ecotoxicological substances, improves feed efficiency, and reduces fecal malodor.

Keywords

Acknowledgement

이 논문은 농림축산식품의 재원으로 농림식품기술기획평가원의 유용농생명자원산업화기술개발사업의 지원을 받아 수행된 연구임(No. 321095021CG000).

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