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Analysis of Lactate Dehydrogenase Levels of COVID-19 Patients in a Korean Hospital According to Sex and Age

  • Kim, Sun Gyu (Department of Medical Laser, Dankook University Graduate School of Medicine) ;
  • Song, Hee Seung (Department of Nursing, Sangji University) ;
  • Kim, Jae Kyung (Department of Biomedical Laboratory Science, Dankook University)
  • Received : 2022.11.27
  • Accepted : 2022.12.03
  • Published : 2022.12.31

Abstract

This study aimed to determine whether lactate dehydrogenase (LDH) levels in coronavirus disease (COVID-19) patients in Korea were higher than those in patients without COVID-19, and the effect of sex and age on LDH levels. A retrospective, observational study was conducted to measure LDH levels in 247 and 225 female and male COVID-19 patients, respectively, who were admitted to the study hospital between April 1 and October 30, 2020. Serum LDH levels were measured using an automated analyzer. Results: LDH levels were elevated in both male and female patients with COVID-19. Among patients with COVID-19, LDH levels were higher in males than in females, and LDH levels were higher in patients with COVID-19 than in patients in the control group. In the analysis of differences in LDH levels by age, LDH levels in patients with COVID-19 increased statistically significantly with age in males and females (males: p=0.001, females: p=0.001). By examining the differences in LDH levels according to sex and age, this study contributed to the basic biochemical data available in Korea, particularly regarding patients with COVID-19. Further research may be needed to examine confounding variables.

Keywords

References

  1. T. Singhal. "A review of coronavirus disease-2019 (COVID-19)," Indian Journal of Pediatrics, Vol. 87, pp. 281-286, 2020. DOI: https://doi.org/10.1007/s12098-020-03263-6
  2. World Health Organization. Worldwide, status of COVID-19, 15 Nov 2022, https://covid19.who.int.
  3. Ministry of Health and Welfare. Korea, Domestic status of COVID-19, 15 Nov 2022, https://ncov.kdca.go.kr/?brdId=1&brdGubun=11&ncv
  4. W. Yang, J. Shaman, "COVID-19 pandemic dynamics in India and impact of the SARS-CoV-2 Delta (B.1.617.2) variant." MedRxiv preprint. https://doi.org/0.1101/2021.06.21.21259268; this version posted on June 25, 2021. DOI: https://doi.org/10.1101/2021.06.21.21259268
  5. Y. Lee, P. Min, S. Lee, and S.W. Kim, "Prevalence and duration of acute loss of smell or taste in COVID-19 patients," Journal of Korean Medical Science, Vol. 35, e174, 2020. DOI: https://doi.org/10.3346/jkms.2020.35.e174
  6. J.L. Frater, G. Zini, G. d'Onofrio, and H.J. Rogers, "COVID-19 and the clinical hematology laboratory," International Journal of Laboratory Hematology, Vol. 42, Suppl. 1, pp. 11-18, 2020. DOI: https://doi.org/10.1111/ijlh.13229
  7. G. Lippi and M. Plebani, "The critical role of laboratory medicine during coronavirus disease 2019 (COVID-19) and other viral outbreaks," Clinical Chemistry and Laboratory Medicine, Vol. 58, No. 7, pp. 1063-1069, 2020. DOI: https://doi.org/10.1515/cclm-2020-0240
  8. G. Lippi and M. Plebani, "Laboratory abnormalities in patients with COVID-2019 infection," Clinical Chemistry and Laboratory Medicine, Vol. 58, No. 7, pp. 1131-1134, 2020. DOI: https://doi.org/10.1515/cclm-2020-0198
  9. R. Fang, X. Zheng, and M. Zhang, "Ethyl pyruvate alleviates early brain injury following subarachnoid hemorrhage in rats," Acta Neurochirurgica, Vol. 158, No. 6, pp. 1069-1076, 2016. DOI: https://doi.org/10.1007/s00701-016-2795-3
  10. R. Garcia, J.M. Hernandez, M.D. Caballero, M. Gonzalez, J. Galende, M.C. del Canizo, L. Vazquez, and J.F. San Miguel, "Serum lactate dehydrogenase level as a prognostic factor in Hodgkin's disease," British Journal of Cancer, Vol. 68, No. 6, pp. 1227-1231, 1993. DOI: https://doi.org/10.1038/bjc.1993.509
  11. B. Fialek, M. Pruc, J. Smereka, R. Jas, M. Rahnama-Hezavah, A. Denegri, A. Szarpak, M.J. Jaguszewski, F.W. Peacock, and L. Szarpak, "Diagnostic value of lactate dehydrogenase in COVID-19: A systematic review and meta-analysis," Cardiology Journal. Vol. 29, No. 5, pp. 751-758. DOI: 10.5603/CJ.a2022.0056
  12. P. Mo, Y. Xing, Y. Xiao, L. Deng, Q. Zhao, H. Wang, Y. Xiong, Z. Cheng, S. Gao, K. Liang, M. Luo, T. Chen, S. Song, Z. Ma, X. Chen, R. Zheng, Q. Cao, F. Wang, and Y. Zhang, "Clinical characteristics of refractory COVID19 in Wuhan, China," Clinical Infectious Diseases, Vol. 16, ciaa270, 2020. DOI: 10.1093/cid/ciaa270
  13. D. Ferrari, A. Motta, M. Strollo, M. Locatelli, and G. Banfi, "Routine blood tests as a potential diagnostic tool for COVID-19," Clinical Chemistry and Laboratory Medicine, Vol. 58, pp. 1095-1099, 2020. DOI: 10.1515/cclm-2020-0398
  14. Z. Zheng, F. Peng, B. Xu, J. Zhao, H. Liu, J. Peng, Q. Li, C. Jiang, Y. Zhou, S. Liu, C. Ye, P. Zhang, Y. Xing, H. Guo, and W. Tang, "Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis," Journal of Infection, Vol. 81, No. 2, pp. e16-e25, 2020. DOI: 10.1016/j.jinf.2020.04.021
  15. J. Hu, J. Zhou, F. Dong, J. Tan, S. Wang, Z. Li, X. Zhang, H. Zhang, J. Ming, and T. Huang, "Combination of serum lactate dehydrogenase and sex is predictive of severe disease in patients with COVID-19," Medicine (Baltimore), Vol. 99, No. 42, pp. e22774, 2020. DOI: 10.1097/MD.0000000000022774
  16. H. Ward, C.J. Atchison, M. Whitaker, K.E.C. Ainslie, J. Elliott, L.C. Okell, R. Redd, D. Ashby, C.A. Donnelly, W. Barclay, A. Darzi, G. Cooke, S. Riley, P. Elliott, "Antibody prevalence for SARS-CoV-2 in England following first peak of the pandemic: REACT2 study in 100,000 adults," 2020. MedRxiv preprint. DOI: https://doi.org/10.1101/2020.08.12.20173690.