Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Targeting eosinophils: another strategy for asthma treatment

  • Jee, Hye Mi (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine)
  • 투고 : 2021.01.06
  • 심사 : 2021.02.24
  • 발행 : 2021.05.15
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참고문헌

  1. Engelkes M, Baan EJ, de Ridder MAJ, Svensson E, Prieto-Alhambra D, Lapi F, et al. Incidence, risk factors and re-exacerbation rate of severe asthma exacerbations in a multinational, multidatabase pediatric cohort study. Pediatr Allergy Immunol 2020;31:496-505. https://doi.org/10.1111/pai.13237
  2. Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43:343-73. https://doi.org/10.1183/09031936.00202013
  3. Bossley CJ, Fleming L, Gupta A, Regamey N, Frith J, Oates T, et al. Pediatric severe asthma is characterized by eosinophilia and remodeling without T(H)2 cytokines. J Allergy Clin Immunol 2012;129:974-82.e13. https://doi.org/10.1016/j.jaci.2012.01.059
  4. Payne DN, Qiu Y, Zhu J, Peachey L, Scallan M, Bush A, et al. Airway inflammation in children with difficult asthma: relationships with airflow limitation and persistent symptoms. Thorax 2004;59:862-9. https://doi.org/10.1136/thx.2003.017244
  5. Choi BS. Eosinophils and childhood asthma. Clin Exp Pediatr 2021;64:60-7. https://doi.org/10.3345/cep.2020.00717
  6. Howrylak JA, Fuhlbrigge AL, Strunk RC, Zeiger RS, Weiss ST, Raby BA, et al. Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications. J Allergy Clin Immunol 2014;133:1289-300.e12. https://doi.org/10.1016/j.jaci.2014.02.006
  7. Fitzpatrick AM, Moore WC. Severe asthma phenotypes - how should they guide evaluation and treatment? J Allergy Clin Immunol Pract 2017;5:901-8. https://doi.org/10.1016/j.jaip.2017.05.015
  8. Nelson RK, Bush A, Stokes J, Nair P, Akuthota P. Eosinophilic asthma. J Allergy Clin Immunol Pract 2020;8:465-73. https://doi.org/10.1016/j.jaip.2019.11.024
  9. Fleming L, Tsartsali L, Wilson N, Regamey N, Bush A. Longitudinal relationship between sputum eosinophils and exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med 2013;188:400-2. https://doi.org/10.1164/rccm.201212-2156LE
  10. Jang JH, Woo SD, Lee Y, Kim CK, Shin YS, Ye YM, et al. Changes in type 2 biomarkers after anti-IL5 treatment in patients with severe eosinophilic asthma. Allergy Asthma Immunol Res 2021;13:330-8. https://doi.org/10.4168/aair.2021.13.2.330