Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis

  • Mehri, Fereshteh (Nutrition Health Research Center, Hamadan University of Medical Sciences) ;
  • Bashirian, Saeid (Social Determinants of Health Research Center, Hamadan University of Medical Sciences) ;
  • Khazaei, Salman (Department of Epidemiology, Hamadan University of Medical Sciences) ;
  • Jenabi, Ensiyeh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences)
  • Received : 2020.05.10
  • Accepted : 2020.07.25
  • Published : 2021.06.15
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Abstract

Background: The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear. Purpose: This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children. Methods: We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity. Results: The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26-2.34; and OR, 1.20; 95% CI, 1.02-1.39), respectively. Conclusion: Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.

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References

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