Nutrition Research and Practice

  • 제15권6호
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  • Pages.703-714
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  • 2021
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Effects of a low-FODMAP enteral formula on diarrhea on patients in the intensive care unit

  • Bae, Eunjoo (Department of Food and Nutrition, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Kim, Jiyoon (Department of Food and Nutrition, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Jang, Jinyoung (Department of Neurosurgery, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Kim, Junghyun (Division of Pulmonology, Allergy, and Critical Care Medicine, Department of Internal Medicine, CHA Bundang Medical Center, School of Medicine, CHA University) ;
  • Kim, Suyeon (Department of Pharmacy, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Chang, Youngeun (Department of Food and Nutrition, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • KIM, MI YEON (Department of Nursing, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Jeon, Mira (Department of Nursing, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Kang, Seongsuk (Department of Nursing, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Lee, Jung Keun (Department of Neurosurgery, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Kim, Tae Gon (Department of Neurosurgery, CHA Bundang Medical Center, CHA University School of Medicine)
  • 투고 : 2021.02.16
  • 심사 : 2021.05.13
  • 발행 : 2021.12.01
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초록

BACKGROUND/OBJECTIVES: A dietary restriction on the intake of fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) has been reported to be effective in the treatment of gastrointestinal (GI) tract complications. Enteral nutrition (EN) is widely used for patients who cannot obtain their nutritional requirements orally, but many studies have reported EN complications, especially diarrhea, in up to 50% of patients. SUBJECTS/METHODS: We performed a single-center, non-randomized, controlled trial to determine the effects of a low-FODMAP enteral formula on GI complications in patients in intensive care units (ICUs). Patients in the ICU who needed EN (n = 66) were alternately assigned to the low-FODMAP group (n = 33) or the high-FODMAP group (n = 33). RESULTS: Anthropometric and biochemical parameters were measured, and stool assessment was performed using King's Stool Chart. We excluded patients who received laxatives, GI motility agents, proton pump inhibitors, antifungal agents, and antibiotics other than β-lactams. There were no differences in GI symptoms during 7 days of intervention, including bowel sound, abdominal distension, and vomiting between the 2 groups. However, diarrhea was more frequent in the high-FODMAP group (7/33 patients) than the low-FODMAP group (1/33 patients) (P = 0.044). CONCLUSIONS: Our results suggest that a low-FODMAP enteral formula may be a practical therapeutic approach for patients who exhibit enteral formula complications. Our study warrants further randomized clinical trials and multicenter trials.

키워드

과제정보

The authors would like to thank nutrition support team members and nurses of the intensive care unit for their critical review of the study as well as many patients who participated in this research.

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