Neonatal Medicine

The Korean Society of Neonatology (대한신생아학회)
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Effects of Oxygen Saturation Fluctuations on Retinopathy in Infants Younger than 30 Weeks' Gestational Age

  • Jeon, Chae Woo (Department of Pediatrics, Ajou University School of Medicine) ;
  • Kim, Ji Su (Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center) ;
  • Park, Bumhee (Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center) ;
  • Lee, Jang Hoon (Department of Pediatrics, Ajou University School of Medicine)
  • Received : 2020.07.29
  • Accepted : 2020.10.15
  • Published : 2021.02.28
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Abstract

Purpose: To evaluate the risk factors and effects of fluctuations in oxygen saturation on the occurrence and severity of retinopathy of prematurity (ROP). Methods: From January 1, 2013 to January 31, 2020, 260 patients hospitalized in the neonatal intensive care unit of Ajou University Hospital were retrospectively analyzed. Results: Sixty-six patients (25%) were diagnosed with ROP; of them 39 required treatment. In the multivariate regression analysis of ROP severity, the odds ratio (OR) of gestational age was 0.32 (95% confidence interval [CI], 0.22 to 0.47; P<0.0001). The OR of saturation of peripheral oxygen (SpO2) fluctuations at the 4th week after birth was 1.02 (95% CI, 1.02 to 1.12; P=0.041). Conclusion: SpO2 fluctuations in premature infants younger than 30 weeks' gestational age affects ROP severity, especially at the 4th week of life.

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References

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