Toxicological Research

  • 제37권4호
  • /
  • Pages.429-434
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  • 2021
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Teratogenic effects of ethanol extract of Curcuma mangga Val. rhizomes in wistar rats

  • Yuandani, Yuandani (Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara) ;
  • Tarigan, Krisna Sandra Amalia (Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara) ;
  • Yuliasmi, Sri (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara)
  • 투고 : 2020.04.04
  • 심사 : 2020.11.04
  • 발행 : 2021.10.15
⟨ 이전 논문 다음 논문 ⟩

초록

We have recently highlighted the immunomodulatory effect of ethanol extract of Curcuma mangga Val. rhizomes. The current study was performed to investigate the teratogenic effects of C. mangga extract in Wistar rats. The C. mangga extract at doses of 100, 500 and 1000 mg/kg bw were administered to pregnant rats on day 6-15 of gestation. The litter size, length and birth weight as well as body weight of pregnant rats were determined to evaluate the teratogenic effects of C. mangga extract. External and skeletal malformations were also examined. The extract reduced the litter length compared to normal control (p<0.05). The average body weight gain of the pregnant rats also decreased. Resorption was observed after treatment with extract at the dose of 1000 mg/kg bw. The extract at the doses of 500 and 1000 mg/kg bw reduced litter birth weight and induced external and skeletal malformations. This demonstrates that ethanol extract of C. mangga has teratogenic effects in Wistar rats and should be used with caution in pregnancy.

키워드

과제정보

This work was supported by TALENTA grant scheme, Universitas Sumatera Utara with grant number of 4167/UN5.1.R/PPM/2019.

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