Toxicological Research

  • 제37권4호
  • /
  • Pages.395-403
  • /
  • 2021
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Advantages of omics technology for evaluating cadmium toxicity in zebrafish

  • Min, Eun Ki (Department of Environmental Engineering, Seoul National University of Science and Technology) ;
  • Lee, Ahn Na (College of Pharmacy, Kyungpook National University) ;
  • Lee, Ji-Young (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Shim, Ilseob (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Kim, Pilje (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Kim, Tae-Young (School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology) ;
  • Kim, Ki-Tae (Department of Environmental Engineering, Seoul National University of Science and Technology) ;
  • Lee, Sangkyu (College of Pharmacy, Kyungpook National University)
  • 투고 : 2020.09.28
  • 심사 : 2020.12.17
  • 발행 : 2021.10.15
⟨ 이전 논문 다음 논문 ⟩

초록

In the last decade, several advancements have been made in omics technologies and they have been applied extensively in diverse research areas. Especially in toxicological research, omics technology can efficiently and accurately generate relevant data on the molecular dynamics associated with adverse outcomes. Toxicomics is defined as the combination of toxicology and omics technologies and encompasses toxicogenomics, toxicoproteomics, and toxicometabolomics. This paper reviews the trend of applying omics technologies to evaluate cadmium (Cd) toxicity in zebrafish (D. rerio). Cd is a toxic heavy metal posing several environmental concerns; however, it is being used widely in everyday life. Zebrafish embryos and larvae are employed as standard models for many toxicity tests because they share 71.4% genetic homology with humans. This study summarizes the toxicity of Cd on the nerves, liver, heart, skeleton, etc. of zebrafish and introduces detailed omics techniques to understand the results of the toxicomic studies. Finally, the trend of toxicity evaluation in the zebrafish model of Cd based on omics technology is presented.

키워드

과제정보

This study was partially supported by the National Institute of Environmental Research, Republic of Korea.

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