Korean Chemical Engineering Research

  • 제59권4호
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  • Pages.493-502
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  • 2021
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  • 0304-128X(pISSN)
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  • 2233-9558(eISSN)
한국화학공학회 (The Korean Institute of Chemical Engineers)
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Kinetics, Isotherm and Adsorption Mechanism Studies of Letrozole Loaded Modified and Biosynthesized Silver Nanoparticles as a Drug Delivery System: Comparison of Nonlinear and Linear Analysis

  • PourShaban, Mahsa (Department of Biotechnology, Science and research Branch, Islamic Azad University) ;
  • Moniri, Elham (Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University) ;
  • Safaeijavan, Raheleh (Department of Biochemistry and Biophysics, Varamin-Pishva Branch, Islamic Azad University) ;
  • Panahi, Homayon Ahmad (Department of Chemistry, Central Tehran Branch, Islamic Azad University)
  • 투고 : 2021.01.08
  • 심사 : 2021.08.05
  • 발행 : 2021.11.01
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초록

We prepared and investigated a biosynthesized nanoparticulate system with high adsorption and release capacity of letrozole. Silver nanoparticles (AgNPs) were biosynthesized using olive leaf extract. Cysteine was capped AgNPs to increase the adsorption capacity and suitable interaction between nanoparticles and drug. Morphology and size of nanoparticles were confirmed using transmission electron microscopy (TEM). Nanoparticles were spherical with an average diameter of less than 100 nm. Cysteine capping was successfully confirmed by Fourier transform infrared resonance (FTIR) spectroscopy and elemental analysis (CHN). Also, the factors of letrozole adsorption were optimized and the linear and non-linear forms of isotherms and kinetics were studied. Confirmation of the adsorption data of letrozole by cysteine capped nanoparticles in the Langmuir isotherm model indicated the homogeneous binding site of modified nanoparticles surface. Furthermore, the adsorption rate was kinetically adjusted to the pseudo-second-order model, and a high adsorption rate was observed, indicating that cysteine coated nanoparticles are a promising adsorbent for letrozole delivery. Finally, the kinetic release profile of letrozole loaded modified nanoparticles in simulated gastric and intestinal buffers was studied. Nearly 40% of letrozole was released in simulated gastric fluid with pH 1.2, in 30 min and the rest of it (60%) was released in simulated intestinal fluid with pH 7.4 in 10 h. These results indicate the efficiency of the cysteine capped AgNPs for adsorption and release of drug letrozole for breast cancer therapy.

키워드

과제정보

The results described in this paper were part of student thesis. The authors thank all laboratory staff of Islamic Azad University, Science and Researches Branch. The authors declare no conflict of interest.

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