DOI QR코드

DOI QR Code

A feasibility study of using a 3D-printed tumor model scintillator to verify the energy absorbed to a tumor

  • Kim, Tae Hoon (Department of Nuclear Engineering, Hanyang University College of Engineering) ;
  • Lee, Sangmin (Department of Nuclear Engineering, Hanyang University College of Engineering) ;
  • Kim, Dong Geon (Department of Nuclear Engineering, Hanyang University College of Engineering) ;
  • Jeong, Jae Young (Department of Nuclear Engineering, Hanyang University College of Engineering) ;
  • Yang, Hye Jeong (Department of Biomedicine and Health Sciences & Biomedical Engineering, Catholic University College of Medicine) ;
  • Schaarschmidt, Thomas (Department of Biomedicine and Health Sciences & Biomedical Engineering, Catholic University College of Medicine) ;
  • Choi, Sang Hyoun (Research Team of Radiological Physics and Engineering, Korea Institute of Radiological & Medical Science) ;
  • Cho, Gyu-Seok (Research Team of Radiological Physics and Engineering, Korea Institute of Radiological & Medical Science) ;
  • Kim, Yong Kyun (Department of Nuclear Engineering, Hanyang University College of Engineering) ;
  • Chung, Hyun-Tai (Department of Neurosurgery, Seoul National University College of Medicine)
  • 투고 : 2020.08.14
  • 심사 : 2021.03.31
  • 발행 : 2021.09.25

초록

The authors developed a volumetric dosimetry detector system using in-house 3D-printable plastic scintillator resins. Three tumor model scintillators (TMSs) were developed using magnetic resonance images of a tumor. The detector system consisted of a TMS, an optical fiber, a photomultiplier tube, and an electrometer. The background signal, including the Cherenkov lights generated in the optical fiber, was subtracted from the output signal. The system showed 2.1% instability when the TMS was reassembled. The system efficiencies in collecting lights for a given absorbed energy were determined by calibration at a secondary standard dosimetry laboratory (kSSDL) or by calibration using Monte Carlo simulations (ksim). The TMSs were irradiated in a Gamma Knife® IconTM (Elekta AB, Stockholm, Sweden) following a treatment plan. The energies absorbed to the TMSs were measured and compared with a calculated value. While the measured energy determined with kSSDL was (5.84 ± 3.56) % lower than the calculated value, the energy with ksim was (2.00 ± 0.76) % higher. Although the TMS detector system worked reasonably well in measuring the absorbed energy to a tumor, further improvements in the calibration procedure and system stability are needed for the system to be accepted as a quality assurance tool.

키워드

과제정보

This study was supported by the Ministry of Science and ICT (grant numbers NRF-2016M2A2A6A03946564 and NRF-2020R1F1A1061144).

참고문헌

  1. H.-T. Chung, D.G. Kim, Modern radiosurgery equipment for treating brain metastases, Current and Future Management of Brain Metastasis 25 (2012) 236-247. https://doi.org/10.1159/000331197
  2. N. Agazaryan, T.D. Solberg, J.J. DeMarco, Patient specific quality assurance for the delivery of intensity modulated radiotherapy, J. Appl. Clin. Med. Phys. 4 (1) (2003) 40-50. https://doi.org/10.1120/jacmp.v4i1.2540
  3. J. Malicki, The importance of accurate treatment planning, delivery, and dose verification, Rep. Practical Oncol. Radiother. 17 (2) (2012) 63. https://doi.org/10.1016/j.rpor.2012.02.001
  4. J. Novotny Jr., P. Dvorak, V. Spevacek, J. Tintera, J. Novotny, T. Cechak, R. Liscak, Quality control of the stereotactic radiosurgery procedure with the polymergel dosimetry, Radiother. Oncol. 63 (2) (2002) 223-230. https://doi.org/10.1016/S0167-8140(02)00064-6
  5. S. Beddar, L. Archambault, N. Sahoo, F. Poenisch, G.T. Chen, M.T. Gillin, R. Mohan, Exploration of the potential of liquid scintillators for real-time 3D dosimetry of intensity modulated proton beams, Med. Phys. 36 (5) (2009) 1736-1743. https://doi.org/10.1118/1.3117583
  6. L. Wootton, R. Kudchadker, A. Lee, S. Beddar, Real-time in vivo rectal wall dosimetry using plastic scintillation detectors for patients with prostate cancer, Phys. Med. Biol. 59 (3) (2014) 647. https://doi.org/10.1088/0031-9155/59/3/647
  7. J. Son, D.G. Kim, S. Lee, J. Park, Y. Kim, T. Schaarschmidt, Y.K. Kim, Improved 3D printing plastic scintillator fabrication, J. Kor. Phys. Soc. 73 (7) (2018) 887-892. https://doi.org/10.3938/jkps.73.887
  8. A. Beddar, T. Mackie, F. Attix, Cerenkov light generated in optical fibres and other light pipes irradiated by electron beams, Phys. Med. Biol. 37 (4) (1992) 925. https://doi.org/10.1088/0031-9155/37/4/007
  9. J. Jelley, Cerenkov radiation and its applications, Br. J. Appl. Phys. 6 (7) (1955) 227. https://doi.org/10.1088/0508-3443/6/7/301
  10. L. Archambault, A.S. Beddar, L. Gingras, R. Roy, L. Beaulieu, Measurement accuracy and Cerenkov removal for high performance, high spatial resolution scintillation dosimetry, Med. Phys. 33 (1) (2006) 128-135. https://doi.org/10.1118/1.2138010
  11. G.F. Knoll, Radiation Detection and Measurement, John Wiley & Sons2010.
  12. P. Andreo, D.T. Burns, K. Hohlfeld, M.S. Huq, T. Kanai, F. Laitano, V. Smyth, S. Vynckier, Absorbed Dose Determination in External Beam Radiotherapy: an International Code of Practice for Dosimetry Based on Standards of Absorbed Dose to Water, Iaea Trs, 2000, p. 398.
  13. S. Agostinelli, J. Allison, K.a. Amako, J. Apostolakis, H. Araujo, P. Arce, M. Asai, D. Axen, S. Banerjee, G. Barrand, GEANT4-a simulation toolkit, Nucl. Instrum. Methods Phys. Res. Sect. A Accel. Spectrom. Detect. Assoc. Equip. 506 (3) (2003) 250-303. https://doi.org/10.1016/S0168-9002(03)01368-8
  14. J. Allison, K. Amako, J. Apostolakis, H. Araujo, P.A. Dubois, M. Asai, G. Barrand, R. Capra, S. Chauvie, R. Chytracek, Geant4 developments and applications, IEEE Trans. Nucl. Sci. 53 (1) (2006) 270-278. https://doi.org/10.1109/TNS.2006.869826
  15. T.H. Kim, T. Schaarschmidt, H.J. Yang, Y.K. Kim, K.J. Chun, Y. Choi, H.-T. Chung, Development of an IAEA phase-space dataset for the Leksell gamma Knife® PerfexionTM using multi-threaded Geant4 simulations, Phys. Med. 64 (2019) 222-229. https://doi.org/10.1016/j.ejmp.2019.07.002
  16. C.M. Poole, I. Cornelius, J.V. Trapp, C.M. Langton, A cad interface for geant4, Australas, Phys. Eng. Sci. Med. 35 (3) (2012) 329-334. https://doi.org/10.1007/s13246-012-0159-8
  17. S. Vatnisky, A. Meghzifene, K. Christaki, H. Palmans, P. Andrew, M. Saiful Huq, Dosimetry of Small Fields Used in External Beam Radiotherapy: an International Code of Practice for Reference and Relative Dose Determination, International Atomic Energy Agency, 2017. IAEA TRS-483.
  18. T. Schaarschmidt, T.H. Kim, Y.K. Kim, H.J. Yang, H.-T. Chung, GEANT4-based Monte Carlo simulation of beam quality correction factors for the Leksell gamma Knife® PerfexionTM, J. Kor. Phys. Soc. 73 (12) (2018) 1814-1820. https://doi.org/10.3938/jkps.73.1814
  19. S.-G. Crystals, BC-400, BC-404, BC-408, BC-412, BC-416 Premium Plastic Scintillators, Saint-Gobain Crystals, Nemours, 2005.
  20. E.J. Hall, A.J. Giaccia, Radiobiology for the Radiologist, Philadelphia, 2006.