대한약침학회지 (Journal of Pharmacopuncture)

  • 제24권3호
  • /
  • Pages.107-121
  • /
  • 2021
  • /
  • 2093-6966(pISSN)
  • /
  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
권호 표지
DOI QR코드

DOI QR Code

A Meta-Analysis of Treatment Effects on Viral Pneumonia Using TCM Injections Specified in the Clinical Guideline for COVID-19 in China

  • Chun, Hea Sun (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University) ;
  • Choi, Su Hyeon (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University) ;
  • Song, Ho Sueb (Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Gachon University)
  • 투고 : 2021.09.03
  • 심사 : 2021.09.07
  • 발행 : 2021.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The purpose of this study is to analyze the efficacy of traditional Chinese medicine (TCM) injections specified in the clinical guideline for COVID-19 by conducting a meta-analysis of viral pneumonia data. Methods: TCM injections data on viral pneumonia were collected until July 31, 2021. CNKI, PubMed, EMBASE, and the Cochrane electronic database were used to collect the clinical data. "COVID-19," "Viral pneumonia," "Tanreqing," "Xiyanping," "Reduning," "Xingnaojing," "Xuebijing," "Shenmai," "Shengmai," and "Shenfu" were used as keywords. All data collected were mainly about TCM injections and viral pneumonia. Furthermore, studies that included results such as the total effective rate, cough disappearance time, antipyretic time, lung rhomboid disappearance time, and adverse drug reaction were collected for the meta-analysis to identify the efficacy of TCM injections. However, data unrelated to TCM injections specified in the clinical guidelines for COVID-19 or viral pneumonia were excluded. The quality of included RCTs was assessed by the Cochrane Risk of Bias Tool, and Review Manager 5.3 software was used to conduct the meta-analysis. Results: A total of 18 studies with 1540 patients were included in this study. The results of the meta-analysis showed that the total effective rate OR = 4.61 (95% CI 2.92, 7.25, p = 1.00/ I2 = 0%); the cough disappearance time: SMD -1.23 (-1.37, -1.09, p < 0.00001/ I2 = 94%); the antipyretic time: SMD -1.26 (-1.40, -1.11, p < 0.00001/ I2=94%); lung rhomboid disappearance time: SMD -1.17 (-1.33, -1.02, p < 0.00001/ I2 = 89%); and adverse drug reaction was OR 0.36 (95% CI 0.20, 0.64, p = 0.21/ I2 = 30%). From the results, the treatment group (TCM injection) showed better efficacy than the control group (Western medication). Conclusion: Xiyanping, Reduning, and Tanreqing injections may yield benefits as COVID-19 treatments. However, clinical trials on TCM injections for the treatment of COVID-19 are still lacking. More high-quality clinical trials are still required.

키워드

참고문헌

  1. World Health Organization. Coronavirus Disease (COVID-19) Pandemic [Internet]. Geneva: World Health Organization; c2021 [cited 2020 Mar 11]. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
  2. Shi Y, Wang G, Cai XP, Deng JW, Zheng L, Zhu HH, et al. An overview of COVID-19. J Zhejiang Univ Sci B. 2020;21(5):343-60. https://doi.org/10.1631/jzus.B2000083
  3. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) [Internet]. Baltimore (MD): Johns Hopkins University & Medicine; c2021 [cited 2021 Aug 15]. Available from: https://coronavirus.jhu.edu/map.html.
  4. COVID-19 [Internet]. Sejong: Ministry of Health and Welfare; [cited 2021 Aug 1]. Available from: http://ncov.mohw.go.kr/.
  5. Li Y, Tenchov R, Smoot J, Liu C, Watkins S, Zhou Q. A comprehensive review of the global efforts on COVID-19 vaccine development. ACS Cent Sci. 2021;7(4):512-33. https://doi.org/10.1021/acscentsci.1c00120
  6. Zhai P, Ding Y, Wu X, Long J, Zhong Y, Li Y. The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents. 2020;55(5):105955. https://doi.org/10.1016/j.ijantimicag.2020.105955
  7. Zeng CY, Cao HL, Mei CX. Key points for rational use and drug monitoring of traditional Chinese medicine injections in the COVID-19 diagnosis and treatment scheme (trial version 7). China Pharm. 2020;23(5):878-83.
  8. National Medical Health Office. [2021] 191. Novel Coronavirus Pneumonia Diagnosis and Guideline (Trial Version 8, Revised Version) [Internet]. Beijing: The General Office of National Health Commission Office of State TCM Administration; 2021 Apr 15 [cited 2021 Aug 30]. Available from: http://www.nhc.gov.cn/yzygj/s7653p/202104/7de0b3837c8b4606a0594aeb0105232b.shtml. Chinese.
  9. State Pharmacopoeia Committee of China. [Chinese pharmacopoeia]. Beijing: The Medicine Science and Technology Press of China; 2020. Chinese.
  10. Yao ZH [Internet]. Zhongqing: YAOZH.COM; c2009-2021 [cited 2021 Jul 10]. Available from: www.yaozh.com. Chinese.
  11. Sun RJ. [Therapeutic effect of Xiyanping Injection on viral pneumonia in children]. Cardiovasc Dis J Integr Tradit Chin West Med. 2018;6(4):62. Chinese.
  12. Bai TM, Da CS. Curative effect of Xiyanping injection in the treatment of children with viral pneumonia. Shaanxi J Tradi Chin Med. 2017;38(10):1354-5.
  13. Ren ZD, Bao YB, Xu HB. [Clinical efficacy of Xiyanping injection in the treatment of infantile viral pneumonia]. China J Pharm Econ. 2014;Suppl 1:169-70. Chinese.
  14. Pan YR. [Therapeutic effect of Xiyanping Injection on 35 cases of viral pneumonia in children]. Chin Pediatr Integr Tradit West Med. 2011;3(5):415-6. Chinese.
  15. Li YJ. [Therapeutic effect of Xiyanping on viral pneumonia in children]. Qingdao Med J. 2006;38(3):176-7. Chinese.
  16. Meng Z, Pei LW. [Effect analysis of Xiyanping in the treatment of viral pneumonia]. J Clin Med Lit. 2014;1(11):1938-9. Chinese.
  17. Zhao WL. [Effect of Xiyanping in the treatment of viral pneumonia]. J North Pharm. 2013;10(12):40-1. Chinese.
  18. Chen JY, Zhao MS, Cao XH. [Clinical observation of Xiyanping injection in the treatment of viral pneumonia]. J Binzhou Med Coll. 2003;26(3):217-8. Chinese.
  19. Cao SB. [Effect of Reduning Injection on viral pneumonia in children]. Chin J Clin Ration Drug Use. 2019;12(34):113-4. Chinese.
  20. Zou WK. [Effect of Reduning Injection on viral pneumonia in children]. Contemp Med Forum. 2014;12(21):167-9. Chinese.
  21. Liao YZ, Guo WZ, Lu SY. [Clinical observation of Reduning Injection in the treatment of viral pneumonia in children]. Chin J Mod Drug Appl. 2008;2(19):34-5. Chinese.
  22. Zhao RF. [Clinical observation of Tanreqing Injection in the treatment of viral pneumonia in children]. J Emerg Tradit Chin Med. 2013;22(9):1596-7. Chinese.
  23. Meng QJ, Zhang LF, Li GJ. [Therapeutic effect of Tanreqing on viral pneumonia in children]. Public Med Forum Mag. 2006;10(7):340-1. Chinese. https://doi.org/10.3969/j.issn.1672-1721.2006.07.032
  24. Li Q. [Therapeutic effect of Xiyanping on 90 cases of viral pneumonia]. J Ningxia Med Univ. 2009;31(6):781-2. Chinese. https://doi.org/10.3969/j.issn.1674-6309.2009.06.029
  25. Jia DM, Yang YJ. [Treatment of 60 cases of viral pneumonia in children with Tanreqing Injection]. Cent Plains Med J. 2006;33(4):69-70. Chinese. https://doi.org/10.3760/cma.j.issn.1674-4756.2006.04.052
  26. Lv XH, Dong CH, Zhu YH. Tanreqing injection in the treatment of children's viral pneumonia: observation of clinical efficacy. China Pharm. 2007;18(33):2611-2.
  27. Xiong ZY, Liu J, Fu JP. [Efficacy and safety analysis of Reduning Injection in the treatment of viral pneumonia in children]. Contemp Med. 2017;23(11):116-7. Chinese.
  28. Zhang XG, Han ZB, Han JX, Dong CH. [Therapeutic effect of Reduning Injection on 60 cases of viral pneumonia in children]. Qilu Pharm Aff. 2008;27(3):178-9. Chinese. https://doi.org/10.3969/j.issn.1672-7738.2008.03.029
  29. Jiang K, Tian QJ, Bao XH, Xu ZR. [Analysis and consideration of adverse drug reaction in traditional Chinese medicine injection]. Mod Med J China. 2021;23(4):93-8. Chinese.
  30. Wu QG, Zhang XL, Song YP. [The current situation and outlet of traditional Chinese medicine injection]. Chin Foreign Med Res. 2019;17(36):185-8. Chinese.
  31. Zhang XY, Lv L, Zhou YL, Xie LD, Xu Q, Zou XF, et al. Efficacy and safety of Xiyanping injection in the treatment of COVID-19: a multicenter, prospective, open-label and randomized controlled trial. Phytother Res. 2021;35(8):4401-10. https://doi.org/10.1002/ptr.7141
  32. Huang WH, Teng LC, Yeh TK, Chen YJ, Lo WJ, Wu MJ, et al. 2019 novel coronavirus disease (COVID-19) in Taiwan: reports of two cases from Wuhan, China. J Microbiol Immunol Infect. 2020;53(3):481-4. https://doi.org/10.1016/j.jmii.2020.02.009
  33. Shi H, Han X, Jiang N, Cao Y, Alwalid O, Gu J, et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis. 2020;20(4):425-34. https://doi.org/10.1016/s1473-3099(20)30086-4
  34. An SU. A reference to the original source of herb-acupuncture in methods. J Yakchim (Korean Herb-Acupuncture) Inst. 1997;1(1):87-102.
  35. Song GE, Lim GM, Lee YG, Song GJ, Park SJ. A review of a clinical study on pharmacopuncture for insomnia in China. J Orient Neuropsychiatry. 2019;30(3):265-74. https://doi.org/10.7231/JON.2019.30.3.265
  36. Li H, Xiong N, Li C, Gong Y, Liu L, Yang H, et al. Efficacy of ribavirin and interferon-α therapy for hospitalized patients with COVID-19: a multicenter, retrospective cohort study. Int J Infect Dis. 2021;104:641-8. https://doi.org/10.1016/j.ijid.2021.01.055