Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Melixyloidin, A New Acridone Alkaloid from Melicope xanthoxyloides Leaves

  • Saputri, Ratih Dewi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya) ;
  • Tanjung, Mulyadi (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga) ;
  • Tjahjandarie, Tjitjik Srie (Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga)
  • Received : 2021.07.10
  • Accepted : 2021.09.02
  • Published : 2021.09.30
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Abstract

A new acridone alkaloid, melixyloidin (1), and two known alkaloids (2-3) were isolated from Melicope xanthoxyloides (F. Muell) T.G. Hartley leaves. The structure of melixyloidin were elucidated using NMR spectra and high-resolution ESIMS data. Acridone alkaloids 1-3 were evaluated against MCF-7 and HeLa cells. 1,3,4-Trimethoxy-10-methylacridin-9-one (2) showed potent cytotoxic activity against MCF-7 cells with an IC50 value of 5.31 μM.

Keywords

Acknowledgement

This work was supported by the Hibah Mandat Grant, Universitas Airlangga, Indonesia, 2019.

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