Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
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Evaluation of the wound healing ability of an Abeliophyllum distichum Nakai extract in ICR mouse and of antibacterial activity against human cutaneous flora

  • Go, Young Bin (Division of Food and Animal Science, Chungbuk National University) ;
  • Lee, Ji Hwan (Division of Food and Animal Science, Chungbuk National University) ;
  • Oh, Han Jin (Division of Food and Animal Science, Chungbuk National University) ;
  • Kim, Yong Ju (Division of Food and Animal Science, Chungbuk National University) ;
  • An, Jae Woo (Division of Food and Animal Science, Chungbuk National University) ;
  • Chang, Se Yeon (Division of Food and Animal Science, Chungbuk National University) ;
  • Song, Dong Cheol (Division of Food and Animal Science, Chungbuk National University) ;
  • Cho, Hyun Ah (Division of Food and Animal Science, Chungbuk National University) ;
  • Cho, Jin Ho (Division of Food and Animal Science, Chungbuk National University)
  • Received : 2021.05.31
  • Accepted : 2021.07.22
  • Published : 2021.09.01
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Abstract

In this study, we evaluated the wound healing rate and, inflammatory cells effects of by Abeliophyllum distichum Nakai (ADN) extract in mice. We also assessed the stability of the ADN extract upon exposure to sunlight. Treatments were as follows: 1) CON (only saline solution), T1 (CON + 0.0125% ADN extract), T2 (CON + 0.05% ADN extract), and T3 (CON + 0.5% ADN extract). A 4 mm punch was used in the central part of the dorsal area to separate it from the subcutaneous tissue, causing a full-thickness skin wound. An amount of 1 mL of each sample was sprayed onto the treatment section of the wound with a pipette every day from the day of wound creation, with proper application ensured using brush. In the stability test, the pH was measured at 1, 4, and 8 weeks after exposing the samples of each treatment section to sunlight considering, the higher concentrations of the ADN extract. The results of this study indicate that the effectiveness of the wound contraction rate in the mice to which the ADN extract was applied was low. Moreover, the stability of the sample containing a high concentration of the ADN extract could not be verified. In addition, no significant results were obtained in the inflammatory reaction assessment. Therefore, additional research focusing on wound contraction, stability, and inflammatory cell outcomes of the ADN extract is needed.

Keywords

Acknowledgement

This result was supported by "Regional Innovation Strategy (RIS)" through the National Research Foundation of Korea (NRF) funded by the Ministry of Education(MOE).

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