Molecules and Cells

  • 제44권8호
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  • Pages.613-622
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  • 2021
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  • 1016-8478(pISSN)
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  • 0219-1032(eISSN)
한국분자세포생물학회 (Korean Society for Molecular and Cellular Biology)
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Retinoid Metabolism in the Degeneration of Pten-Deficient Mouse Retinal Pigment Epithelium

  • Kim, You-Joung (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Park, Sooyeon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Ha, Taejeong (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Seungbeom (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Lim, Soyeon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • You, Han (School of Life Sciences, Xiamen University) ;
  • Kim, Jin Woo (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST))
  • 투고 : 2021.05.31
  • 심사 : 2021.06.07
  • 발행 : 2021.08.31
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초록

In vertebrate eyes, the retinal pigment epithelium (RPE) provides structural and functional homeostasis to the retina. The RPE takes up retinol (ROL) to be dehydrogenated and isomerized to 11-cis-retinaldehyde (11-cis-RAL), which is a functional photopigment in mammalian photoreceptors. As excessive ROL is toxic, the RPE must also establish mechanisms to protect against ROL toxicity. Here, we found that the levels of retinol dehydrogenases (RDHs) are commonly decreased in phosphatase tensin homolog (Pten)-deficient mouse RPE, which degenerates due to elevated ROL and that can be rescued by feeding a ROL-free diet. We also identified that RDH gene expression is regulated by forkhead box O (FOXO) transcription factors, which are inactivated by hyperactive Akt in the Pten-deficient mouse RPE. Together, our findings suggest that a homeostatic pathway comprising PTEN, FOXO, and RDH can protect the RPE from ROL toxicity.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grants funded by Korean Ministry of Science and ICT (MSIT) (2017R1A2B3002862 and 2018R1A5A1024261; J.W.K.); the grant funded by Samsung Foundation of Science and Technology (SSTF-BA1802-10; J.W.K.).

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