Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Anticoccidial Activity of Berberine against Eimeria-Infected Chickens

  • Nguyen, Binh Thanh (College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University) ;
  • Flores, Rochelle Alipio (College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University) ;
  • Cammayo, Paula Leona Taymen (College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University) ;
  • Kim, Suk (College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University) ;
  • Kim, Woo Hyun (College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University) ;
  • Min, Wongi (College of Veterinary Medicine & Institute of Animal Medicine, Gyeongsang National University)
  • Received : 2021.05.29
  • Accepted : 2021.07.30
  • Published : 2021.08.31
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Abstract

Avian coccidiosis has a major economic impact on the poultry industry, it is caused by 7 species of Eimeria, and has been primarily controlled using chemotherapeutic agents. Due to the emergence of drug-resistant strains, alternative control strategies are needed. We assessed anticoccidial effects of berberine-based diets in broiler chickens following oral infection with 5 Eimeria species (E. acervulina, E. maxima, E. tenella, E. mitis, and E. praecox). When 0.2% berberine, a concentration that does not affect weight gain, was added to the diet, the 4 groups infected with E. acervulina, E. tenella, E. mitis, or E. praecox showed significant reductions in fecal oocyst shedding (P<0.05) compared to their respective infected and untreated controls. In chickens treated 0.5% berberine instead of 0.2% and infected with E. maxima, fecal oocyst production was significantly reduced, but body weight deceased, indicating that berberine treatment was not useful for E. maxima infection. Taken together, these results illustrate the applicability of berberine for prophylactic use to control most Eimeria infections except E. maxima. Further studies on the mechanisms underlying the differences in anticoccidial susceptibility to berberine, particularly E. maxima, are remained.

Keywords

Acknowledgement

This research was supported by the Basic Science Research Program through the NRF of Korea funded by the Ministry of Education (2018R1D1A1B07045179) and IPET in Food, Agriculture, Forestry and Fisheries through the Agriculture, Food and Rural Affairs Research Center Support Program, funded by MAFRA (716002-7).

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