Journal of Microbiology and Biotechnology

  • 제31권8호
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  • Pages.1109-1114
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  • 2021
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Role of Interleukin-4 (IL-4) in Respiratory Infection and Allergy Caused by Early-Life Chlamydia Infection

  • Li, Shujun (Department of Clinical Laboratory, People's Hospital of Xing'an League) ;
  • Wang, Lijuan (Department of Five Sense Organs, People's Hospital of Xing'an League) ;
  • Zhang, Yulong (Department of Clinical Laboratory, People's Hospital of Xing'an League) ;
  • Ma, Long (Department of Clinical Laboratory, People's Hospital of Xing'an League) ;
  • Zhang, Jing (Department of Clinical Laboratory, People's Hospital of Xing'an League) ;
  • Zu, Jianbing (Department of Clinical Laboratory, People's Hospital of Xing'an League) ;
  • Wu, Xuecheng (Department of Clinical Laboratory, Shenzhen People's Hospital)
  • 투고 : 2021.04.21
  • 심사 : 2021.06.26
  • 발행 : 2021.08.28
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초록

Chlamydia pneumoniae is a type of pathogenic gram-negative bacteria that causes various respiratory tract infections including asthma. Chlamydia species infect humans and cause respiratory infection by rupturing the lining of the respiratory which includes the throat, lungs and windpipe. Meanwhile, the function of interleukin-4 (IL-4) in Ch. pneumoniae respiratory infection and its association with the development of airway hyperresponsiveness (AHR) in adulthood and causing allergic airway disease (AAD) are not understood properly. We therefore investigated the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. In this study, Ch. pneumonia strain was propagated and cultured in HEp-2 cells according to standard protocol and infant C57BL/6 mice around 3-4 weeks old were infected to study the role of IL-4 in respiratory infection and allergy caused by early life Chlamydia infection. We observed that IL-4 is linked with Chlamydia respiratory infection and its absence lowers respiratory infection. IL-4R α2 is also responsible for controlling the IL-4 signaling pathway and averts the progression of infection and inflammation. Furthermore, the IL-4 signaling pathway also influences infection-induced AHR and aids in increasing AAD severity. STAT6 also promotes respiratory infection caused by Ch. pneumoniae and further enhanced its downstream process. Our study concluded that IL-4 is a potential target for preventing infection-induced AHR and severe asthma.

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