Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Development of an exclusive column method for 82Sr/82Rb generator using a 100 MeV proton linear accelerator of KOMAC

  • Kye-Ryung Kim (Korea Atomic Energy Research Institute(KAERI)) ;
  • Yeong Su Ha (Korea Atomic Energy Research Institute(KAERI)) ;
  • Sang-Pil Yoon (Korea Atomic Energy Research Institute(KAERI)) ;
  • Yeon-ji Lee (Korea Atomic Energy Research Institute(KAERI)) ;
  • Yong-Sub Cho (Korea Atomic Energy Research Institute(KAERI)) ;
  • Hyeongi Kim (Korea Institute of Radiological & Medical Sciences(KIRAMS)) ;
  • Sang-Jin Han (Korea Institute of Radiological & Medical Sciences(KIRAMS)) ;
  • Jung Young Kim (Korea Institute of Radiological & Medical Sciences(KIRAMS)) ;
  • Kyo Chul Lee (Korea Institute of Radiological & Medical Sciences(KIRAMS)) ;
  • Jin Su Kim (Korea Institute of Radiological & Medical Sciences(KIRAMS))
  • Received : 2021.12.22
  • Accepted : 2021.12.28
  • Published : 2021.12.30
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Abstract

82Sr for 82Rb generator was produced through the irradiation of the proton beam on the nat.RbCI target at the target irradiation facility installed at the end of the Rl-dedicated beamline of the 100 MeV proton linear accelerator of KOMAC (Korea Multi-purpose Accelerator Complex). The average current of the proton beam was 1.2 µA for irradiation time of 150 min. For the separation and purification of the 82Sr from nat.RbCI irradiated, Chelex-100 resin was used. The activities of 82Sr in the irradiated nat.RbCI target solution and after purification were 45.29 µCi and 43.4 µCi, respectively. The separation and purification yield was 95.8%. As an adsorbent to be filled in the generator for 82Sr adsorption hydrous tin oxide was selected. The adsorption yield of 82Sr into the generator adsorbent was > 99 %, and the total amount of 82Sr adsorbed to the generator was 21.6 µCi as of the day of the 82Rb elution experiment. When the elution amount was 22 mL, the maximum82Rb elution yield was 93.3%, and the elution yield increased as the flow rate increased. After the eluted 82Rb was filled in the correction phantom of the small PET for animals, a PET image was taken. The image scan time was set to 5 min, and the phantom PET image was successfully obtained. As results of impurity analysis on eluted 82Rb using ICP-MS, nat.Rb stable isotopes that compete in vivo of 82Rb were identified as undetected levels and were determined to be No-Carrier-Added (NCA).

Keywords

Acknowledgement

본 연구는 과학기술정보통신부의 방사선공학기술개발사업 '고에너지 양성자가속기 이용 82Sr 생산 및 방생기 기술 개발' 과제(NRF-2017M2A2A2A05016601)의 일환으로 수행되었습니다.

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