Korean Journal of Organic Agriculture (한국유기농업학회지)

Korean Association of Organic Agriculture (한국유기농업학회)
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Effect of Intestinal Tight Junction Protein Expression on Growth Performance for Eco-friendly Broiler Production: Meta-analysis

친환경 육계 생산을 위한 장 점막 밀접 접합 단백질의 발현량 조절이 생산성에 미치는 효과: Meta-analysis

  • 전은정 (전북대학교 축산학과) ;
  • 박명선 (전북대학교 축산학과) ;
  • 한재규 (전북대학교 축산학과) ;
  • 김정용 (전북대학교 축산학과) ;
  • 안성일 (전북대학교 농업생명과학대학 동물자원과학과)
  • Received : 2021.01.20
  • Accepted : 2021.02.19
  • Published : 2021.02.27
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Abstract

In this study, a meta-analysis was performed to determine the correlation between the expression of tight junction protein in the intestine and the productivity of broiler chickens. A total of 9 papers were selected in which the result values consisted of the mean and standard deviation value, and the standardized mean difference was calculated to compare the mean of the control and treatment groups. A meta-regression test was conducted to determine the effect of each type of tight junction protein. The TJPs observed in each study were claudin1, claudin2, claudin3, occludin, ZO1, ZO2, etc., and the indicators to indicate the productivity of broilers were body weight gain (BWG), feed intake (FI), and feed conversion rate (FCR), average daily feed intake (ADFI), average daily gain (ADG), and feed/gain ratio (FPG). Although there are differences depending on the type of TJP, it was found that the change in expression level had a close effect on the productivity of broilers. In particular, occludin significantly correlated with body weight gain, feed intake, and feed conversion rate. Based on the results of this study, a study on a method to effectively increase the expression level of TJP is expected to contribute to improving the productivity of broilers and producing safe livestock products.

본 연구에서는 meta-analysis를 통해 TJP의 발현량과 육계의 생산성 간의 상관관계를 살펴보았다. TJP의 발현량은 생산성의 향상과 밀접한 관계가 있는 것으로 나타났으며, 특히 occludin의 발현이 육계의 생산성과 가장 큰 상관관계를 보이는 것으로 나타났다. Occludin 발현량 조절과 장 점막 건강이 육계 생산성 향상을 위한 영양 관리 전략 지표로 활용될 수 있을 것이다.

Keywords

Acknowledgement

이 성과는 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(No. 2020R1C1C1010982).

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