Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Metabolite Profiling of Serum from Patients with Tuberculosis

  • Park, Hee-Bin (Division of Bacterial Disease Research, Center for Infectious Diseases Research, National Institute of Infectious Disease (NIID)) ;
  • Yoo, Min-Gyu (Division of Endocrine and Kidney Disease Research, Department of Chronic Disease Convergence Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency) ;
  • Choi, Sangho (Division of Bacterial Disease Research, Center for Infectious Diseases Research, National Institute of Infectious Disease (NIID)) ;
  • Kim, Seong-Han (Division of Bacterial Disease Research, Center for Infectious Diseases Research, National Institute of Infectious Disease (NIID)) ;
  • Chu, Hyuk (Division of Bacterial Disease Research, Center for Infectious Diseases Research, National Institute of Infectious Disease (NIID))
  • Received : 2021.01.20
  • Accepted : 2021.03.03
  • Published : 2021.06.28
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Abstract

Tuberculosis (TB) is a major infectious disease that threatens the life and health of people globally. Here, we performed a metabolomic analysis of serum samples from patients with intractable TB to identify biomarkers that might shorten the TB treatment period. Serum samples collected at the commencement of patients' treatment and healthy controls were analyzed using the capillary electrophoresis and time-of-flight mass spectrometry metabolome analysis method. The analysis identified the metabolites cystine, kynurenine, glyceric acid, and cystathionine, which might be useful markers for monitoring the TB treatment course. Furthermore, our research may provide experimental data to develop potential biomarkers in the TB treatment course.

Keywords

Acknowledgement

The study was supported by a research grant (2019-NG038-01) of Korea Centers for Disease Control and Prevention.

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