대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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한방치료 후 NK세포 활성도의 호전을 보인 암환자 증례보고 3례

3 Cases of Cancer Patients Whose Natural Killer Cell Activity Improved with Traditional Korean Medicine Treatment: A Case Series

  • 박찬란 (대전대학교 대학원 한의학과 간계내과학교실) ;
  • 김은지 (대전대학교 대학원 한의학과 간계내과학교실) ;
  • 손창규 (대전대학교 대학원 한의학과 간계내과학교실) ;
  • 조정효 (대전대학교 대학원 한의학과 간계내과학교실) ;
  • 이남헌 (대전대학교 대학원 한의학과 간계내과학교실)
  • Park, Chan-ran (Dept. of Hepatology & Hematology, Graduated School of Korean Medicine, Daejeon University) ;
  • Kim, Eun-ji (Dept. of Hepatology & Hematology, Graduated School of Korean Medicine, Daejeon University) ;
  • Son, Chang-gue (Dept. of Hepatology & Hematology, Graduated School of Korean Medicine, Daejeon University) ;
  • Cho, Jung-hyo (Dept. of Hepatology & Hematology, Graduated School of Korean Medicine, Daejeon University) ;
  • Lee, Nam-hun (Dept. of Hepatology & Hematology, Graduated School of Korean Medicine, Daejeon University)
  • 투고 : 2021.05.25
  • 심사 : 2021.06.18
  • 발행 : 2021.06.30
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초록

Objectives: High natural killer cell activity (NKA) is associated with a clinically favorable status in patients with cancer. This study explores whether traditional Korean medicine (TKM) improves NKA in patients with cancer. Methods: We report three clinical cases involving patients with cancer who underwent NKA tests while they received TKM treatment, including acupuncture, moxibustion, wild ginseng pharmacopuncture, and Korean herbal medicines. We analyzed the treatment process and NKA test results of each patient. Results: The NKA of all three patients presented with an increasing tendency during the treatment process. Patient 1, who had been diagnosed with breast cancer, received inpatient treatment 3 times between September 16, 2017 and February 27, 2019. The NKA increased from 7.2 pg/mL to 571.7 pg/mL. Patient 2, who had thyroid cancer, was hospitalized 4 times between July 23, 2019 and August 27, 2020. The NKA improved from 317.4 pg/mL to 2000 pg/mL. Patient 3, who had liver cancer, received inpatient treatment 4 times between May 27, 2016 and January 10, 2017. The NKA increased from 22.2 pg/mL to 459.5 pg/mL. The chief complaints of these patients also were alleviated. Conclusions: TKM may be an effective treatment for accelerating NKA. Further research is needed to establish evidence that TKM stimulates NKA.

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과제정보

이 연구는 대한민국 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 연구임(NRF-2020R1F1A1069711).

참고문헌

  1. Hong S, Won YJ, Park YR, Jung KW, Kong HJ, Lee ES, et al. Cancer statistics in Korea: Incidence, mortality, survival, and prevalence in 2017. Cancer Res Treat 2020;52(2):335-50. https://doi.org/10.4143/crt.2020.206
  2. Statistics Korea Vital statistics division, Shin HY, Kim J, Lee S, Park MS, Park S, et al. Cause-of-death statistics in 2018 in the Republic of Korea. J Korean Med Assoc 2020;63(5):286-97. https://doi.org/10.5124/jkma.2020.63.5.286
  3. Yoon SW, Jeong JS, Kim JH, Aggarwal BB. Cancer prevention and therapy: Integrating traditional Korean medicine into modern cancer care. Integr Cancer Ther 2014;13(4):310-31. https://doi.org/10.1177/1534735413510023
  4. Bae K, Kim E, Choi JJ, Kim MK, Yoo HS. The effectiveness of anticancer traditional Korean medicine treatment on the survival in patients with lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer: A prospective cohort study protocol. Medicine 2018;97(41):e12444. https://doi.org/10.1097/md.0000000000012444
  5. Park JH, Son CG, Cho CK. A literature study on oncological immune therapy. Journal of Haehwa Medicine 2001;9(2):211-21.
  6. Kim HS. Natural killer cell and cancer Immunotherapy. Hanyang Med Rev 2013;33(1):59-64. https://doi.org/10.7599/hmr.2013.33.1.59
  7. Spits H, Di Santo JP. The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling. Nat Immunol 2011;12(1):21-7. https://doi.org/10.1038/ni.1962
  8. Chan CJ, Smyth MJ, Martinet L. Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ 2014;21(1):5-14. https://doi.org/10.1038/cdd.2013.26
  9. Smyth MJ, Hayakawa Y, Takeda K, Yagita H. New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2002;2(11) :850-61. https://doi.org/10.1038/nrc928
  10. Hansen TF, Nederby L, Zedan AH, Mejiholm I, Henriksen JR, Steffensen KD, et al. Correlation between natural killer cell activity and treatment effect in patients with disseminated cancer. Transl Oncol 2019;12(7):968-72. https://doi.org/10.1016/j.tranon.2019.04.002
  11. Tang YP, Xie MZ, Li KZ, Li JL, Cai ZM, Hu BL. Prognostic value of peripheral blood natural killer cells in colorectal cancer. BMC Gastroenterol 2020;20(1):1-8. https://doi.org/10.1186/s12876-019-1136-4
  12. Jobin G, Rodriguez-Suarez R, Betito K. Association between natural killer cell activity and colorectal cancer in high-risk subjects undergoing colonoscopy. Gastroenterology 2017;153(4):980-7. https://doi.org/10.1053/j.gastro.2017.06.009
  13. Imai K, Matsuyama S, Miyake S, Suga K, Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet 2000;356(9244):1795-9. https://doi.org/10.1016/S0140-6736(00)03231-1
  14. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982;5(6):649-55. https://doi.org/10.1097/00000421-198212000-00014
  15. 탁원영. Clinical Significance of Serum HBsAg Titer. Single Topic Symposium 2014;2014(1):1-8.
  16. Castriconi R, Daga A, Dondero A, Zona G, Poliani PL, Melotti A, et al. NK cells recognize and kill human glioblastoma cells with stem cell-like properties. J Immunol 2009;182(6):3530-9. https://doi.org/10.4049/jimmunol.0802845
  17. NKMAX. NK Vue® kit range of application. Available at : https://nkmax.com/eng/bbs/content.php?co_id=kit_nkcell. Accessed May 17, 2021.
  18. Lee HS, Leem G, Kang H, Jo JH, Chung MJ, Jang SJ, et al. Peripheral natural killer cell activity is associated with poor clinical outcomes in pancreatic ductal adenocarcinoma. J Gastroenterol Hepatol 2021;36(2):516-22. https://doi.org/10.1111/jgh.15265
  19. Kang HJ, Bae K, Kim JH, Cho CK, Yoo HS. Correlation between natural killer cell activity and systemic inflammatory markers for heterogeneous cancer patients treated with Wheel Balance Cancer Therapy. Integr Cancer Ther 2018;17(2):322-31. https://doi.org/10.1177/1534735417717789
  20. Yoon J, Cho CK, Shin JE, Yoo HS. Changes in the laboratory data for cancer patients treated with Korean-medicine-based inpatient care. J Pharmacopuncture 2014;17(1):20-6. https://doi.org/10.3831/KPI.2014.17.003
  21. Johnston MF, Ortiz Sanchez E, Vujanovic NL, Li W. Acupuncture may stimulate anticancer immunity via activation of natural killer cells. Evidence-based Complement Altern Med 2011;2011:481625.
  22. Qiu X, Chen K, Tong L, Shu X, Lu X, Wen H, et al. Effects of moxibustion at Shenque (CV 8) on serum IL-12 level and NK cell activities in mice with transplanted tumor. J Tradit Chinese Med 2004;24(1):56-8. https://doi.org/10.3969/j.issn.0255-2922.2004.01.023
  23. 대한약침학회 학술위원회, 약침의학연구소. 약 침학. 2판. 서울: 엘스비어코리아; 2011, p. 229-46.
  24. Cho BJ, Kwon KR. Effects of cultivated wild ginseng herbal acupuncture to the serum cytokine on hepatic metastatic model using colon 26-L5 carcinoma cells. J Pharmacopuncture 2006;9(1):127-37. https://doi.org/10.3831/KPI.2006.9.1.127
  25. Park BK, Cho CK, Kwon KR, Yoo HS. A case report for stage III B Squamous cell lung carcinoma patient treated with cultured wild ginseng pharmacopuncture therapy. J Pharmacopuncture 2007;10(3):143-7. https://doi.org/10.3831/KPI.2007.10.3.143
  26. Goodrich SK, Schlegel CR, Wang G, Belinson JL. Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: A review. Futur Oncol 2014;10(4):647-54. https://doi.org/10.2217/fon.13.228
  27. Park KK, Chun KS, Lee JM, Lee SS, Surh YJ. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett 1998;129(2):139-44. https://doi.org/10.1016/S0304-3835(98)00081-0
  28. Jun HJ, Park SJ, Kang HJ, Lee GY, Lee N, Park JH, et al. The survival benefit of combination therapy with mild temperature hyperthermia and an herbal prescription of Gun-Chil-Jung in 54 cancer patients treated with chemotherapy or radiation therapy: a retrospective study. Integr Cancer Ther 2020;19:1872145015.
  29. Yoo HS, Lee YY, Song KC, Choi BL, Seo SH, Chol JH, et al. The effects of HangAmDan (HAD) on anti-metastasis and preventing relapses, administered to 69 cancer patients. Korean J Orient Intern Med 2002;23(2):165-73.
  30. Park HR, Lee EJ, Moon SC, Chung TW, Kim KJ, Yoo HS, et al. Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype. Oncol Lett 2017;13(4):2330-6. https://doi.org/10.3892/ol.2017.5730
  31. Yim MH, Shin JW, Son JY, Oh SM, Han SH, Cho JH, et al. Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes. Acta Pharmacol Sin 2007;28(6):901-7. https://doi.org/10.1111/j.1745-7254.2007.00577.x
  32. Xue X, Liao W, Xing Y. Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma. Infect Agent Cancer 2020;15(1):1-6. https://doi.org/10.1186/s13027-019-0268-z