Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of Korean Red Ginseng through comparative analysis of cardiac gene expression in db/db mice

  • Jang, Young-Jin (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Aravinthan, Adithan (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Hossain, Mohammad Amjad (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kopalli, Spandana Rajendra (Department of Integrative Bioscience and Biotechnology, Sejong University) ;
  • Kim, Bumseok (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kim, Nam Soo (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kang, Chang-Won (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kim, Jong-Hoon (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
  • Received : 2020.04.14
  • Accepted : 2020.06.21
  • Published : 2021.05.01
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Abstract

Korean Red Ginseng (KRG) is an herbal oriental medicine known to alleviate cardiovascular dysfunction. To analysis the expression of diabetic cardiac complication-associated genes in db/db mice, we studied the cardiac gene expression following KRG treatment. In result, a total of 585 genes were found to be changed in db/db mice. Among the changed expression, 245 genes were found to 2-fold upregulated, and 340 genes were 2-fold downregulated. In addition, the changed gene expressions were ameliorated by KRG. In conclusion, KRG may be possible to normalize cardiac gene expressions in db/db mice.

Keywords

Acknowledgement

This work was supported by the 2013 grant from the Korean Society of Ginseng funded by Korea Ginseng Corporation.

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