DOI QR코드

DOI QR Code

A Korean nationwide investigation of the national trend of complex regional pain syndrome vis-à-vis age-structural transformations

  • Lee, Joon-Ho (Department of Anesthesiology and Pain Medicine, Soonchunhyang University Bucheon Hospital) ;
  • Park, Suyeon (Department of Data Innovation, Soonchunhyang University Seoul Hospital) ;
  • Kim, Jae Heon (Department of Urology, Soonchunhyang University Seoul Hospital)
  • 투고 : 2021.02.24
  • 심사 : 2021.04.23
  • 발행 : 2021.07.01

초록

Background: The present study employed National Health Insurance Data to explore complex regional pain syndrome (CRPS) updated epidemiology in a Korean context. Methods: A CRPS cohort for the period 2009-2016 was created based on Korean Standard Classification of Diseases codes alongside the national registry. The general CRPS incidence rate and the yearly incidence rate trend for every CRPS type were respectively the primary and secondary outcomes. Among the analyzed risk factors were age, sex, region, and hospital level for the yearly trend of the incidence rate for every CRPS. Statistical analysis was performed via the chi-square test and the linear and logistic linear regression tests. Results: Over the research period, the number of registered patients was 122,210. The general CRPS incidence rate was 15.83 per 100,000, with 19.5 for type 1 and 12.1 for type 2. The condition exhibited a declining trend according to its overall occurrence, particularly in the case of type 2 (P < 0.001). On the other hand, registration was more pervasive among type 1 compared to type 2 patients (61.7% vs. 38.3%), while both types affected female individuals to a greater extent. Regarding age, individuals older than 60 years of age were associated with the highest prevalence in both types, regardless of sex (P < 0.001). Conclusions: CRPS displayed an overall incidence of 15.83 per 100,000 in Korea and a declining trend for every age group which showed a negative association with the aging shift phenomenon.

키워드

과제정보

This work was supported by Soonchunhyang University Research Fund.

참고문헌

  1. Stanton-Hicks M, Janig W, Hassenbusch S, Haddox JD, Boas R, Wilson P. Reflex sympathetic dystrophy: changing concepts and taxonomy. Pain 1995; 63: 127-33. https://doi.org/10.1016/0304-3959(95)00110-E
  2. Dotson RM. Causalgia--reflex sympathetic dystrophy--sympathetically maintained pain: myth and reality. Muscle Nerve 1993; 16: 1049-55. https://doi.org/10.1002/mus.880161008
  3. Rowbotham MC. Complex regional pain syndrome type I (reflex sympathetic dystrophy): more than a myth. Neurology 1998; 51: 4-5. https://doi.org/10.1212/WNL.51.1.4
  4. Wasner G, Backonja MM, Baron R. Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. Neurol Clin 1998; 16: 851-68. https://doi.org/10.1016/S0733-8619(05)70101-8
  5. Sandroni P, Benrud-Larson LM, McClelland RL, Low PA. Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain 2003; 103: 199-207. https://doi.org/10.1016/S0304-3959(03)00065-4
  6. Ochoa JL. Reflex sympathetic dystrophy: a disease of medical understanding. Clin J Pain 1992; 8: 363-6. https://doi.org/10.1097/00002508-199212000-00012
  7. Kim YC. Complex regional pain syndrome. Korean J Pain 2004; 17 Suppl: 104-8.
  8. Rho RH, Brewer RP, Lamer TJ, Wilson PR. Complex regional pain syndrome. Mayo Clin Proc 2002; 77: 174-80. https://doi.org/10.1016/S0025-6196(11)62332-X
  9. Ratti C, Nordio A, Resmini G, Murena L. Post-traumatic complex regional pain syndrome: clinical features and epidemiology. Clin Cases Miner Bone Metab 2015; 12(Suppl 1): 11-6.
  10. Harden NR, Bruehl S, Perez RSGM, Birklein F, Marinus J, Maihofner C, et al. Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome. Pain 2010; 150: 268-74. https://doi.org/10.1016/j.pain.2010.04.030
  11. Birklein F, Schlereth T. Complex regional pain syndromesignificant progress in understanding. Pain 2015; 156 Suppl 1: S94-103. https://doi.org/10.1097/01.j.pain.0000460344.54470.20
  12. Verdugo RJ, Bell LA, Campero M, Salvat F, Tripplett B, Sonnad J, et al. Spectrum of cutaneous hyperalgesias/allodynias in neuropathic pain patients. Acta Neurol Scand 2004; 110: 368-76. https://doi.org/10.1111/j.1600-0404.2004.00341.x
  13. Shim H, Rose J, Halle S, Shekane P. Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth 2019; 123: e424-33. https://doi.org/10.1016/j.bja.2019.03.030
  14. Jeong S, An J, Cho S. Role of affective instability on suicidal risk in complex regional pain syndrome: a diary approach (preliminary report). Korean J Pain 2021; 34: 94-105. https://doi.org/10.3344/kjp.2021.34.1.94
  15. de Mos M, de Bruijn AG, Huygen FJ, Dieleman JP, Stricker BH, Sturkenboom MC. The incidence of complex regional pain syndrome: a population-based study. Pain 2007; 129: 12-20. https://doi.org/10.1016/j.pain.2006.09.008
  16. Allen G, Galer BS, Schwartz L. Epidemiology of complex regional pain syndrome: a retrospective chart review of 134 patients. Pain 1999; 80: 539-44. https://doi.org/10.1016/S0304-3959(98)00246-2
  17. Kim H, Lee CH, Kim SH, Kim YD. Epidemiology of complex regional pain syndrome in Korea: an electronic population health data study. PLoS One 2018; 13: e0198147. https://doi.org/10.1371/journal.pone.0198147
  18. Choi YS, Lee MG, Lee HM, Lee CJ, Jo JY, Jeon SY, et al. Epidemiology of complex regional pain syndrome: a retrospective chart review of 150 Korean patients. J Korean Med Sci 2008; 23: 772-5. https://doi.org/10.3346/jkms.2008.23.5.772
  19. Baek MJ, Park S, Kim KH, Kim YH, Kim WK, Sun HY, et al. National trend of uroflowmetry, urodynamic study and cystoscopy considering the change in the population structure in Korea from 2010 to 2015. J Korean Med Sci 2018; 33: e145. https://doi.org/10.3346/jkms.2018.33.e145
  20. Lee HJ, Lee CS, Yoo Y, Noh JM, Yu JH, Kim YC, et al. Complex regional pain syndrome in the young male population: a retrospective study of 200 Korean young male patients. Korean J Pain 2019; 32: 292-300. https://doi.org/10.3344/kjp.2019.32.4.292