Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Experimental Models for SARS-CoV-2 Infection

  • Kim, Taewoo (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Lee, Jeong Seok (GENOME INSIGHT Inc.) ;
  • Ju, Young Seok (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST))
  • Received : 2021.04.14
  • Accepted : 2021.06.16
  • Published : 2021.06.30
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Abstract

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a novel virus that causes coronavirus disease 2019 (COVID-19). To understand the identity, functional characteristics and therapeutic targets of the virus and the diseases, appropriate infection models that recapitulate the in vivo pathophysiology of the viral infection are necessary. This article reviews the various infection models, including Vero cells, human cell lines, organoids, and animal models, and discusses their advantages and disadvantages. This knowledge will be helpful for establishing an efficient system for defense against emerging infectious diseases.

Keywords

Acknowledgement

This work was supported by the Suh Kyungbae Foundation (SUHF-18010082), the National Research Foundation of Korea (Leading Researcher Program NRF-2020R1A3B2078973), and the Human Frontier Science Program Research Grant (RGY0071/2018).

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