Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Multi-omics integration strategies for animal epigenetic studies - A review

  • Kim, Do-Young (Department of Animal Science and Technology, Chung-Ang University) ;
  • Kim, Jun-Mo (Department of Animal Science and Technology, Chung-Ang University)
  • Received : 2021.01.27
  • Accepted : 2021.04.21
  • Published : 2021.08.01
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Abstract

Genome-wide studies provide considerable insights into the genetic background of animals; however, the inheritance of several heritable factors cannot be elucidated. Epigenetics explains these heritabilities, including those of genes influenced by environmental factors. Knowledge of the mechanisms underlying epigenetics enables understanding the processes of gene regulation through interactions with the environment. Recently developed next-generation sequencing (NGS) technologies help understand the interactional changes in epigenetic mechanisms. There are large sets of NGS data available; however, the integrative data analysis approaches still have limitations with regard to reliably interpreting the epigenetic changes. This review focuses on the epigenetic mechanisms and profiling methods and multi-omics integration methods that can provide comprehensive biological insights in animal genetic studies.

Keywords

Acknowledgement

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1A6A1A03025159). This research was supported by the Chung-Ang University Graduate Research Scholarship in 2021.

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