Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Expert Opinions and Recommendations for the Clinical Use of Quantitative Analysis Software for MRI-Based Brain Volumetry

뇌 자기공명영상 뇌용적 분석 소프트웨어의 임상적 적용에 대한 전문가 의견과 권고안

  • Ji Young Lee (Department of Radiology, Hanyang University Medical Center, Hanyang University Medical College) ;
  • Ji Eun Park (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Mi Sun Chung (Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine) ;
  • Se Won Oh (Department of Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Won-Jin Moon (Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine) ;
  • Aging and Neurodegeneration Imaging (ANDI) Study Group, Korean Society of Neuroradiology (KSNR) (Korean Society of Neuroradiology (KSNR))
  • 이지영 (한양대학교 의과대학 한양대학교병원 영상의학과) ;
  • 박지은 (울산대학교 의과대학 서울아산병원 영상의학과) ;
  • 정미선 (중앙대학교 의과대학 중앙대병원 영상의학과) ;
  • 오세원 (가톨릭대학교 의과대학 은평성모병원 영상의학과) ;
  • 문원진 (건국대학교 의학전문대학원 건국대학교병원 영상의학과) ;
  • 대한신경두경부영상의학회 및 산하 퇴행성신경질환연구회 (대한신경두경부영상의학회)
  • Received : 2020.10.07
  • Accepted : 2021.01.21
  • Published : 2021.09.01
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Abstract

The objective assessment of atrophy and the measurement of brain volume is important in the early diagnosis of dementia and neurodegenerative diseases. Recently, several MR-based volumetry software have been developed. For their clinical application, several issues arise, including the standardization of image acquisition and their validation of software. Additionally, it is important to highlight the diagnostic performance of the volumetry software based on expert opinions. We instituted a task force within the Korean Society of Neuroradiology to develop guidelines for the clinical use of MR-based brain volumetry software. In this review, we introduce the commercially available software and compare their diagnostic performances. We suggest the need for a standard protocol for image acquisition, the validation of the software, and evaluations of the limitations of the software related to clinical practice. We present recommendations for the clinical applications of commercially available software for volumetry based on the expert opinions of the Korean Society of Neuroradiology.

치매를 비롯한 퇴행성 신경 질환의 초기 진단에 자기공명영상을 이용한 뇌 위축 평가와 정량적 용적 분석이 중요하다. 뇌 위축의 시각적 평가는 주관적으로 평가자에 따라 다른 결과를 보여주기 때문에, 객관적인 결과를 제공하면서 임상 적용도 가능한 소프트웨어의 수요와 개발이 늘어나고 있다. 이러한 임상용 소프트웨어의 실제 임상 적용은 영상 검사의 표준화가 선행되어야 하고, 개발된 소프트웨어의 검증이 반드시 필요하다. 따라서 대한신경두경부영상의학회는 뇌용적 분석 임상용 소프트웨어의 임상적 활용에 대한 의견을 제시하기 위해 전문위원회를 구성하고 현재까지 발표된 연구를 정리하였다. 그리고, 정량화 분석을 위한 영상 검사의 표준화 및 소프트웨어의 임상 적용에 대한 전문가 의견을 제시하기 위하여 공동 작업을 수행하였다. 본 종설에서는 뇌 자기공명영상의 정량화 분석의 필요성 및 배경, 정량화 분석을 위한 임상용 소프트웨어의 소개 및 기존의 표준품(reference standard)과의 진단능 비교, 영상 획득의 표준화, 분석 및 평가의 표준화, 소프트웨어의 임상 적용에 대한 전문가 의견, 제한점 및 대처 방법 등 대한신경두경부영상의학회의 전문가 권고안을 소개하는 것이 목적이다.

Keywords

Acknowledgement

KSNR Taskforce on degenerative disease members are as following in alphabetical order: Sung Tae Kim, MD (Sungkyunkwan University School of Medicine), Seul Kee Kim (Chonnam National University Medical School), Ji Hoon Kim, MD (Seoul National University College of Medicine), Mina Park (Yonsei University College of Medicine), Sun Won Park, MD (Seoul National University College of Medicine), Sung Jun Ahn (Yonsei University College of Medicine), Kyung Mi Lee (Kyung Hee University College of Medicine), Geon-Ho Jahng (Kyung Hee University Hospital at Gangdong, College of Medicine), Jinhee Jang (College of Medicine, Catholic University of Korea), Chi-Hoon Choi (Chungbuk National University College of Medicine), Hyun Seok Choi (Yonsei University College of Medicine). The authors sincerely thank Sam-Soo Kim Kim, MD and Kook-Jin Ahn MD for their most valuable advice and support in developing recommendations.

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