Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
권호 표지
DOI QR코드

DOI QR Code

Lymphomatoid Granulomatosis Involving the Lung and Brain in a Child: A Case Report

소아 환자의 폐와 뇌에 발생한 림프종모양육아종증: 증례 보고

  • Sook Min Hwang (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • So-Young Yoo (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Ji Hye Kim (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Tae Yeon Jeon (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sae Lin Oh (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Eun Yoon Cho (Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Bo-Kyung Je (Department of Radiology, Ansan Hospital, Korea University College of Medicine)
  • 황숙민 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 유소영 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 김지혜 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 전태연 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 오세린 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 조은윤 (성균관대학교 의과대학 삼성서울병원 병리과) ;
  • 제보경 (고려대학교 의과대학 안산병원 영상의학과)
  • Received : 2019.10.30
  • Accepted : 2020.05.02
  • Published : 2021.01.01
Download PDF
⟨ Previous Next ⟩

Abstract

Lymphomatoid granulomatosis (LG) is a rare B-cell type angiocentric lymphoproliferative disease that can progress to extranodal lymphoma with high mortality. It most commonly affects the lungs, although extrapulmonary systems, including the brain and skin, can also be involved. LG in pediatric patients has been very rarely reported in the literature with limited imaging features. Herein, we report a pediatric case of LG involving the lung and brain with characteristic imaging findings.

림프종모양육아종증은 드문 B 세포형 림프세포증식병으로 추후 림프종으로 발전할 수 있는 높은 치사율을 가진 질병이다. 이는 주로 폐를 침범하며, 흔하진 않지만 뇌, 피부에도 발병할 수 있다. 소아 환자에서 림프종모양육아종증은 매우 드물게 보고된 질병으로 영상의학적 소견의 보고 또한 매우 적다. 저자들은 소아 환자에서 폐와 뇌에서 발병한 림프종모양육아종증 증례와 이의 특징적 영상의학적 소견에 대해 보고하고자 한다.

Keywords

References

  1. Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum Pathol 1972;3:457-558
  2. Tacke ZC, Eikelenboom MJ, Vermeulen RJ, Van der Knaap MS, Euser AM, Van der Valk P, et al. Childhood lymphomatoid granulomatosis: a report of 2 cases and review of the literature. J Pediatr Hematol Oncol 2014;36:e416-422
  3. Lee JS, Tuder R, Lynch DA. Lymphomatoid granulomatosis: radiologic features and pathologic correlations. AJR Am J Roentgenol 2000;175:1335-1339
  4. Lee S, Kang MJ, Kim HJ, Kim HB, Lee J. Pulmonary lymphomatoid granulomatosis in a 4-year-old girl. Pediatr Radiol 2015;45:1082-1085
  5. Katzenstein AL, Doxtader E, Narendra S. Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surg Pathol 2010;34:e35-48
  6. Myers JL, Kurtin PJ, Katzenstein AL, Tazelaar HD, Colby TV, Strickler JG, et al. Lymphomatoid granulomatosis. Evidence of immunophenotypic diversity and relationship to Epstein-Barr virus infection. Am J Surg Pathol 1995;19:1300-1312
  7. Rezai P, Hart EM, Patel SK. Case 169: lymphomatoid granulomatosis. Radiology 2011;259:604-609
  8. Tateishi U, Terae S, Ogata A, Sawamura Y, Suzuki Y, Abe S, et al. MR imaging of the brain in lymphomatoid granulomatosis. AJNR Am J Neuroradiol 2001;22:1283-1290
  9. Kendi AT, McKinney AM, Clark HB, Kieffer SA. A pediatric case of low-grade lymphomatoid granulomatosis presenting with a cerebellar mass. AJNR Am J Neuroradiol 2007;28:1803-1805
  10. Dunleavy K, Roschewski M, Wilson WH. Lymphomatoid granulomatosis and other Epstein-Barr virus associated lymphoproliferative processes. Curr Hematol Malig Rep 2012;7:208-215