Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Ginseng polysaccharides: A potential neuroprotective agent

  • Wang, Na (School of Pharmacy, Shandong University of Traditional Chinese Medicine) ;
  • Wang, Xianlei (National Oceanographic Center) ;
  • He, Mengjiao (School of Pharmacy, Shandong University of Traditional Chinese Medicine) ;
  • Zheng, Wenxiu (School of Pharmacy, Shandong University of Traditional Chinese Medicine) ;
  • Qi, Dongmei (Experimental center, Shandong University of Traditional Chinese Medicine) ;
  • Zhang, Yongqing (School of Pharmacy, Shandong University of Traditional Chinese Medicine) ;
  • Han, Chun-chao (School of Pharmacy, Shandong University of Traditional Chinese Medicine)
  • Received : 2020.03.05
  • Accepted : 2020.09.05
  • Published : 2021.03.01
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Abstract

The treatments of nervous system diseases (NSDs) have long been difficult issues for researchers because of their complexity of pathogenesis. With the advent of aging society, searching for effective treatments of NSDs has become a hot topic. Ginseng polysaccharides (GP), as the main biologically active substance in ginseng, has various biological properties in immune-regulation, anti-oxidant, anti-inflammation and etc. Considering the association between the effects of GP and the pathogenesis of neurological disorders, many related experiments have been conducted in recent years. In this paper, we reviewed previous studies about the effects and mechanisms of GP on diseases related to nervous system. We found GP play an ameliorative role on NSDs through the regulation of immune system, inflammatory response, oxidative damage and signaling pathway. Structure-activity relationship was also discussed and summarized. In addition, we provided new insights into GP as promising neuroprotective agent for its further development and utilization.

Keywords

Acknowledgement

This work was supported by the Project of Shandong Province Key Research and Development Program [Grant No. 2017YYSP030]. Ji'nan Science and Technology Project [Grant No. 201303055]. Major Science and Technology Innovation in Shandong Province [Grant No. 2017CXGC1307]. Key Laboratory of Classical Theory of Traditional Chinese Medicine, Ministry of Education. Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic research and Traditional Chinese Medicine Resources and Utilization Innovation Team.

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