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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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The Golgi complex: a hub of the secretory pathway

  • Park, Kunyou (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Ju, Sungeun (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Kim, Nari (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Park, Seung-Yeol (Department of Life Sciences, Pohang University of Science and Technology)
  • Received : 2020.11.18
  • Accepted : 2021.02.09
  • Published : 2021.05.31
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Abstract

The Golgi complex plays a central role in protein secretion by regulating cargo sorting and trafficking. As these processes are of functional importance to cell polarity, motility, growth, and division, there is considerable interest in achieving a comprehensive understanding of Golgi complex biology. However, the unique stack structure of this organelle has been a major hurdle to our understanding of how proteins are secreted through the Golgi apparatus. Herein, we summarize available relevant research to gain an understanding of protein secretion via the Golgi complex. This includes the molecular mechanisms of intra-Golgi trafficking and cargo export in the trans-Golgi network. Moreover, we review recent insights on signaling pathways regulated by the Golgi complex and their physiological significance.

Keywords

Acknowledgement

This study was supported by grants from the National Research Foundation (NRF-2020R1C1C1008823, NRF-2017R1A5A1015366), the Korea Health Industry Development Institute (KHIDI-HR20C0025), POSCO Science Fellowship, and the BK21 Plus and BK21 FOUR Research Fellowship.

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