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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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The soma-germline communication: implications for somatic and reproductive aging

  • Gaddy, Matthew A. (Department of Internal Medicine, Division of Hematology/Oncology, Brody School of Medicine at East Carolina University) ;
  • Kuang, Swana (Department of Internal Medicine, Division of Hematology/Oncology, Brody School of Medicine at East Carolina University) ;
  • Alfhili, Mohammad A. (Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University) ;
  • Lee, Myon Hee (Department of Internal Medicine, Division of Hematology/Oncology, Brody School of Medicine at East Carolina University)
  • Received : 2020.09.14
  • Accepted : 2020.12.13
  • Published : 2021.05.31
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Abstract

Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates - worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates.

Keywords

Acknowledgement

We thank members of the Lee laboratory and ECU Reproductive Biology Interest Group (RBIG) for insightful discussions. We are also grateful to Jiwoo Lee (Hope Middle School, NC, USA) and Jiah Lee (Hope Middle School, NC, USA) for assistance with figures. This work was supported by NIA (AG060373-01) to MHL.

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