Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Inositol Polyphosphate Multikinase Signaling: Multifaceted Functions in Health and Disease

  • Lee, Boah (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Park, Seung Ju (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Hong, Sehoon (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Kyunghan (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST)) ;
  • Kim, Seyun (Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST))
  • Received : 2021.02.25
  • Accepted : 2021.04.15
  • Published : 2021.04.30
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Abstract

Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes from yeasts to mammals, which are synthesized by a complex network of enzymes including inositol phosphate kinases. Among these, inositol polyphosphate multikinase (IPMK) is a promiscuous enzyme with broad substrate specificity, which phosphorylates multiple inositol phosphates, as well as phosphatidylinositol 4,5-bisphosphate. In addition to its catalytic actions, IPMK is known to non-catalytically control major signaling events via direct protein-protein interactions. In this review, we describe the general characteristics of IPMK, highlight its pleiotropic roles in various physiological and pathological conditions, and discuss future challenges in the field of IPMK signaling pathways.

Keywords

Acknowledgement

We thank all the members of the Kim lab for discussion and helpful comments. We feel sorry for not citing the work of many other IPMK investigators owing to space constraints. This work was supported by KAIST Advanced Institute for Science-X Fellowship (to S.J.P.) and the National Research Foundation of Korea (NRF-2020R1I1A1A01073144 to S.J.P.; NRF-2020R1A2C3005765 to S.K.).

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