Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지
DOI QR코드

DOI QR Code

Risk Factor of Mood Disorder Development in Breast Cancer Survivors

유방암 생존자의 기분장애 발생 위험요인

  • Park, Min Ae (Medical Informatics and health Technology (MIT), Department of Health Care Management, College of Social Science, Gachon University) ;
  • Seo, Hwa Jeong (Medical Informatics and health Technology (MIT), Department of Health Care Management, College of Social Science, Gachon University)
  • 박민애 (가천대학교 사회과학대학 의료경영학과) ;
  • 서화정 (가천대학교 사회과학대학 의료경영학과)
  • Received : 2020.08.13
  • Accepted : 2020.12.15
  • Published : 2021.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : The questionnaire-based study model has a problem in that there is no information on diseases and drugs to determine the association between mood disorders and the severity of comorbid diseases in cancer survivors. This study used claim data collected by the National Health Insurance Corporation over nine years to identify risk factors of mood disorders in breast cancer survivors Methods : 2,065 patients were included in this study, excluding someone who were diagnosed mood disorders one year before breast cancer diagnosis. All statistical analysis was performed with R4.0.0 Chi-Square test and Cox's proportional hazards model was performed. Results : Chi-square test was performed to confirm the general characteristics of the subjects. There were 461 (22.32%) patients with mood disorders and 1,604 (77.67%) patients with no mood disorders. In the univariate Model 1 according to the CCI, the HR in the case of CCI 2 was analyzed as 1.629(95% CI, 1.15-2.30), CCI≥3 was analyzed as 2.031(95% CI 1.48-2.78), compared to the study subjects with CCI=0. The age and survivorship adjusted Model 2 HR, CCI=2 was 1.615(95% CI, 1.14-2.28), CCI≥3 was analyzed as 1.924 (95% CI 1.40-2.65). The fully adjusted Model 3 HR, CCI=2 was 1.599 (95% CI, 1.12-2.28), CCI≥3 was analyzed as 1.760 (95% CI 1.25-2.49). Conclusion : In order to improve the long-term quality of life for breast cancer survivors in the future, it is necessary to manage survivorship, the severity of comorbidities, which are identified as risk factors for the development of mood disorders.

Keywords

Acknowledgement

This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (1420210) and funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1A2B4006545).

References

  1. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2017, Ministry of Health and Welfare, 2019.
  2. Ng HS, Koczwara B, Roder DM, Niyonsenga T, Vitry AI. Comorbidities in Australian women with hormone-dependeant breast cancer: a populaion-based analysis. Med J Aust 2018;208:24-28. https://doi.org/10.5694/mja17.00006
  3. Lee JE, Shin DW, Cho BL. The current status of cancer survivorship care and a consideration of appropriate care model in Korea. Korean Journal of Clinical Oncology 2014;10:58-62. https://doi.org/10.14216/kjco.14012
  4. Park JH, Bae SH, Chun M, Jung YS, Jung YM. Factors influencing elevated distress scores at the end of primary treatment of breast cancer. Asian Oncol Nurs 2015;15:132-139. https://doi.org/10.5388/aon.2015.15.3.132
  5. Hegel MT, Moore CP, Collins ED, Kearing S, Gillock KL, Riggs RL, et al. Distress, psychiatric syndromes, and impairment of function in women with newly diagnosed breast cancer. Cancer 2006;107:2924-2931. https://doi.org/10.1002/cncr.22335
  6. Mehnert A, Brahler E, Faller H, Harter M, Keller M, Schulz H, et al. Four-week prevalence of mental disorders in patients with cancer across major tumor entities. J Clin Oncol 2014; 32:3540-3546. https://doi.org/10.1200/JCO.2014.56.0086
  7. Zhang C, Hu G, Biskup E, Qiu X, Zhang H, Zhang H. Depression induced by total mastectomy, breast conserving surgery and breast reconstruction: a systematic review and meta-analysis. World J Surg 2018;42:2076-2085. https://doi.org/10.1007/s00268-018-4477-1
  8. Suppli NP, Johansen C, Christensen J, Kessing LV, Kroman N, Dalton SO. Increased risk for depression after breast cancer: a nationwide population-based cohort study of associated factors in Denmark, 1998-2011. J Clin Oncol 2014;32:3831-3839. https://doi.org/10.1200/JCO.2013.54.0419
  9. Khan S, Khan NA, Rehman AU, Khan I, Samo KA, Memon AS. Levels of depression and anxiety post-mastectomy in breast cancer patients at a Public Sector Hospital in Karachi. Asian Pac J Cancer Prev 2016;17:1337-1340. https://doi.org/10.7314/APJCP.2016.17.3.1337
  10. Khan NF, Ward AM, Watson E, Rose PW. Consulting and prescribing behaviour for anxiety and depression in long-term survivors of cancer in the UK. Eur J Cancer 2010;46:3339-3344. https://doi.org/10.1016/j.ejca.2010.07.035
  11. Ng HS, Koczwara B, Roder DM, Niyonsenga T, Vitry AI. Comorbidities in Australian women with hormone-dependeant breast cancer: a populaion-based analysis. Med J Aust 2018;208:24-28. https://doi.org/10.5694/mja17.00006
  12. Jung SY, Kim SH, Park KH, Kaekal EJ, Lee WH, Choi YY, et al. A systematic review of validation studies on depression rating scales in Korea, with a focus on diagnostic validity information : preliminary study for development of Korean screening tool for depression. Anxiety and Mood 2017;13:53-59. https://doi.org/10.24986/anxmod.2017.13.2.53
  13. Maass SWMC, Roorda C, Berenden AJ, Verhaak PFM, de Bock GH. The prevalence of long-term symptoms of depression and anxiety after breast cancer treatment: a systematic review. Maturitas 2015;82:100-108. https://doi.org/10.1016/j.maturitas.2015.04.010
  14. Suppli NP, Johansen C, Christensen J, Kessing LV, Kroman N, Dalton SO. Increased risk for depression after breast cancer: a nationwide population-based cohort study of associated factors in Denmark, 1998-2011. Increased risk for depression after breast cancer: a nationwide population-based cohort study of associated factors in Denmark, 1998-2011. J Clin Oncol 2014;32:3831-3839. https://doi.org/10.1200/JCO.2013.54.0419
  15. Yang H, Brand JS, Fang F, Chiesa F, Johansson ALV, Hall P, et al. Time-dependent risk of depression, anxiety, and stress-related disorders in patients with invasive and in situ breast cancer. Int J Cancer 2017;140:841-852. https://doi.org/10.1002/ijc.30514
  16. Hung YP, Liu CJ, Tsai CF, Hung MH, Tzeng CH, Liu CY, et al. Incidence and risk of mood disorders in patients with breast cancers in Taiwan: a nationwide population-based study. Psycho-Oncology 2013;22:2227-2234. https://doi.org/10.1002/pon.3277
  17. Seo HJ, Noh DY. Care Pathway for Cancer Survivorship in Korea: Trend of Breast Cancer Pathway from 2003 to 2010. Healthc Inform Res 2017;23:119-125. https://doi.org/10.4258/hir.2017.23.2.119
  18. Hwangbo Y, Kang D, Kang M, Kim S, Lee EK, Kim YA, et al. Incidence of diabetes after cancer development: a Korean national cohort study. JAMA Oncol 2018;4:1099-1105. https://doi.org/10.1001/jamaoncol.2018.1684
  19. Heo JS, Chun MS, Oh YT, Noh OK, Kim LY. Psychiatric comorbidities among breast cancer survivors in South Korea: a nationwide population-based study. Breast Cancer Res Treat 2017;162:151-158. https://doi.org/10.1007/s10549-016-4097-0
  20. Lu D, Andersson TML, Fall K, Hultman CM, Czene K, Valdimarsdottir U, et al. Clinical diagnosis of mental disorders immediately before and after cancer diagnosis: a nationwide matched cohort study in Sweden. JAMA Oncol 2016;2:1188-1196. https://doi.org/10.1001/jamaoncol.2016.0483
  21. Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, et al. Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 2005;43:1130-1139. https://doi.org/10.1097/01.mlr.0000182534.19832.83
  22. Townsend L, Walkup JT, Crystal S, Olfson M. A systematic review of validated methods for identifying depression using administrative data. Pharmacoepidemiol Drug Saf 2012;21 Suppl 1:163-173. https://doi.org/10.1002/pds.2310
  23. Hu LY, Liu CJ, Yeh CM, Lu T, Hu YW, Chen TJ, et al. Depressive disorders among patients with gastric cancer in Taiwan: a nationwide population-based study. BMC Psychiatry 2018;18:272. https://doi.org/10.1186/s12888-018-1859-8
  24. Park BR, Youn SY, Yi KK, Lee SY, Lee JS, Chung SH. The prevalence of depression among patients with the top ten most common cancers in South Korea. Psychiatry Investig 2017;14:618-625. https://doi.org/10.4306/pi.2017.14.5.618
  25. Goldzweig G, Baider L, Rottenberg Y, Andritsch E, Jeremy M. Jacobs. Is age a risk factor for depression among the oldest old with cancer? J Geriatr Oncol 2018;9:476-481. https://doi.org/10.1016/j.jgo.2018.03.011
  26. Hung YP, Liu CJ, Tsai CF, Hung MH, Tzeng CH, Liu CY, et al. Incidence and risk of mood disorders in patients with breast cancers in Taiwan: a nationwide population-based study. Psychooncology 2013;22:2227-2234. https://doi.org/10.1002/pon.3277
  27. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Cancer treatment-induced alterations in muscular fitness and quality of life: the role of exercise training. Ann Oncol 2007;18:1957-1962. https://doi.org/10.1093/annonc/mdm364
  28. Adamsen L, Quist M, Andersen C, Moller T, Herrstedt J, Kronborg D, et al. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy: randomised controlled trial. BMJ. 2009;339:b3410. https://doi.org/10.1136/bmj.b3410