Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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3'-O-Acetyl-24-Epi-7,8-Didehydrocimigenol-3-O-β-D-Xylopryranoside Decreases Amyloid Beta Production in Amyloid Precursor Protein-Transfected HeLa Cells

  • Lee, Sang-Bin (Department of Integrative Biological Sciences and Industry, Sejong University) ;
  • Park, Ansun (Natural Product Research Center, Korea Institute of Science and Technology) ;
  • Ma, Chi Thanh (Department of Pharmacognosy, University of Medicine and Pharmacy at Ho Chi Minh City) ;
  • Kim, Young Ho (College of Pharmacy, Chungnam National University) ;
  • Yang, Hyun Ok (Department of Integrative Biological Sciences and Industry, Sejong University)
  • Received : 2020.11.02
  • Accepted : 2020.12.17
  • Published : 2021.05.01
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Abstract

Extracellular beta amyloid (Aβ) plaques are the neuropathological hallmarks of Alzheimer's disease (AD). Accordingly, reducing Aβ levels is considered a promising strategy for AD prevention. 3'-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside significantly decreased the Aβ production and this effect was accompanied with reduced sAPPβ production known as a soluble ectodomain APP fragment through β-secretases in HeLa cells overexpressing amyloid precursor proteins (APPs). This compound also increased the level of sAPPα, which is a proteolytic fragment of APP by α-secretases. In addition, 3'-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside decreased the protein level of β-secretases, but the protein levels of A disintegrin and metalloproteinase (ADAM) family, especially ADAM10 and ADAM17, are increased. Thus, 3'-O-acetyl-24-epi-7,8-didehydrocimigenol-3-O-β-D-xylopryranoside could be useful in the development of AD treatment in the aspect of amyloid pathology.

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References

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