한국동물생명공학회지 (Journal of Animal Reproduction and Biotechnology)

  • 제36권4호
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  • Pages.169-174
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  • 2021
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  • 2671-4639(pISSN)
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  • 2671-4663(eISSN)
한국동물생명공학회 (The Korean Society of Animal Reproduction and Biotechnology)
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Activating and inactivating mutations of the human, rat, equine and eel luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs)

  • Min, Kwan-Sik (Institute of Genetic Engineering, Hankyong National University) ;
  • Byambaragchaa, Munkhzaya (Institute of Genetic Engineering, Hankyong National University) ;
  • Choi, Seung-Hee (Department of Animal Biotechnology, Graduate School of Hankyong National University) ;
  • Joo, Hyo-Eun (Department of Animal Life Science, Hankyong National University) ;
  • Kim, Sang-Gwon (Department of Animal Life Science, Hankyong National University) ;
  • Kim, Yean-Ji (Department of Animal Life Science, Hankyong National University) ;
  • Park, Gyeong-Eun (Department of Animal Life Science, Hankyong National University)
  • 투고 : 2021.11.19
  • 심사 : 2021.12.03
  • 발행 : 2021.12.31
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초록

Mutations in the luteinizing hormone/chorionic gonadotropin receptors (LH/CGRs), representatives of the G protein-coupled receptor family, have been rapidly identified over the last 20 years. This review aims to compare and analyze the data reported the activating and inactivating mutations of the LH/CGRs between human, rat, equine and fish, specifically (Japanese eel Anguilla japonica). Insights obtained through detailed study of these naturally-occurring mutations provide a further update of structure-function relationship of these receptors. Specifically, we present a variety of data on eel LH/CGR. These results provide important information about LH/CGR function in fish and the regulation of mutations of the highly conserved amino acids in glycoprotein hormone receptors.

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참고문헌

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