한국자원식물학회지 (Korean Journal of Plant Resources)

  • 제34권6호
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  • Pages.503-509
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  • 2021
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  • 1226-3591(pISSN)
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  • 2287-8203(eISSN)
한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지
DOI QR코드

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Undaria pinnatifida Inhibits the Mast Cell-Mediated Inflammatory Response via NF-κB/Caspase-1 Suppression

  • Jeon, Yong-Deok (Department of Korean Pharmacy, Woosuk University) ;
  • Lee, Su-Hyun (Department of Biotechnology and Convergence, Daegu Haany University) ;
  • Kim, Su-Jin (Department of Biotechnology and Convergence, Daegu Haany University)
  • 투고 : 2021.11.12
  • 심사 : 2021.11.26
  • 발행 : 2021.12.01
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초록

Marine sources as potential treatment options for various diseases have been a subject of growing interest. However, information on the anti-inflammatory mechanism employed by Undaria pinnatifida (UP) remains limited. The present study was conducted to investigate the mechanisms of UP on the mast cell-mediated inflammatory response. To determine the pharmacological mechanism of UP in inflammatory reaction, we evaluated the effects of UP on interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α production and nuclear factor-κB (NF-κB) and caspase-1 activation in calcium ionophore A23187 plus phorbol 12-myristate 13-acetate-stimulated human mast cells-1 (HMC-1). The results showed that UP suppressed IL-6, IL-8 and TNF-α production in a dose-dependent manner. Moreover, UP significantly attenuated NF-kB/caspase-1 activation in stimulated HMC-1. Collectively, these findings provide experimental evidence that UP may be a useful candidate for the inflammation-related diseases treatment.

키워드

과제정보

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2021R1G1A1005944and NRF -2021R1F1A1047814).

참고문헌

  1. Birrell, M.A., E. Hardaker, S.Wong, K. McCluskie, M. Catley, A.J. De, R. Newton, S. Haj-Yahia, K.T. Pun, C.J. Watts, R.J. Shaw, T.J. Savage and M.G. Belvisi. 2005. Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma. Am. J. Respir. Crit. Care Med. 172: 962-971. https://doi.org/10.1164/rccm.200412-1647OC
  2. Caughey, G,H. 2016. Mast cell proteases as pharmacological targets. Eur. J. Pharmacol. 778:44-55. https://doi.org/10.1016/j.ejphar.2015.04.045
  3. Etman, S.M., R.A. Mehanna, A.A. Bary, Y.S.R. Elnaggar and O.Y. Abdallah. 2021. Undaria pinnatifida fucoidan nanoparticles loaded with quinacrine attenuate growth and metastasis of pancreatic cancer. Int. J. Biol. Macromol. 170:284-297. https://doi.org/10.1016/j.ijbiomac.2020.12.109
  4. Fedenko, E.S., O.G. Elisyutina, T.M. Filimonova, M.N. Boldyreva, O.V. Burmenskaya, O.Y. Rebrova, A.A. Yarilin and R.M. Khaitov. 2011. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Self Nonself. 2:120-124. https://doi.org/10.4161/self.2.2.16939
  5. Gadaleta, R.M., B. Oldenburg, E.C. Willemsen, M. Spit, S. Murzilli, L. Salvatore, L.W. Klomp, P.D. Siersema, K.J. van Erpecum and S.W. van Mil. 2011. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine. Biochimica. et Biophysic.a Acta. 1812:851-858. https://doi.org/10.1016/j.bbadis.2011.04.005
  6. Galli, S.J., J. Kalesnikoff, M.A. Grimbaldeston, A.M. Piliponsky, C.M. Williams and M. Tsai.2005. Mast cells as "tunable" effector and immunoregulatory cells: Recent advances. Annu. Rev. Immunol. 23:749-786. https://doi.org/10.1146/annurev.immunol.21.120601.141025
  7. Gilmore, T.D. and M.R. Garbati. 2011. Inhibition of NF-κB signaling as a strategy in disease therapy. Curr. Top. Microbiol. Immunol. 349:245-263.
  8. Han, N.R., P.D. Moon, N.R. Kim, H.Y. Kim, H.J. Jeong and H.M. Kim. 2017. Schisandra chinensis and its main constituent schizandrin attenuate allergic reactions by downregulating caspase-1 in ovalbumin-sensitized mice. Am. J. Chin. Med. 45:159-172. https://doi.org/10.1142/S0192415X17500112
  9. Harvima, I.T and G. Nilsson. 2011. Mast cells as regulators of skin inflammation and immunity. Acta. Dermat.o Venereologica. 91:644-650. https://doi.org/10.2340/00015555-1197
  10. Hawiger, J. 2001. Innate immunity and inflammation: A transcriptional paradigm. Immunol. Res. 23:99-109. https://doi.org/10.1385/IR:23:2-3:099
  11. Jemima, E.A., A. Prema and E.B. Thangam. 2014. Functional characterization of histamine H4 receptor on human mast cells. Mol. Immunol. 62:19-28. https://doi.org/10.1016/j.molimm.2014.05.007
  12. Jennifer, C.F. 2018. Imaging the role of inflammation in mood and anxiety-related disorders. Curr. Neuropharmacol. 16:533-558. https://doi.org/10.2174/1570159X15666171123201142
  13. Jung, J.W., S.J. Kim, E.M. Ahn, S.R. Oh, H.J. Lee, J.A. Jeong and J.Y. Lee. 2014. Ribes fasciculatum var. chinense Attenuated Allergic Inflammation In Vivo and In Vitro. Biomol. Ther (Seoul). 22:547-552. https://doi.org/10.4062/biomolther.2014.015
  14. Kim, C.H., Y.K. Lee, J.W. Jeong, B.S. Hwang, Y.T. Jeong, Y.T. Oh, P.Y. Cho and C.H. Kang. 2021. Anti-inflammatory effects of Hemistepta lyrata Bunge in LPS-stimulated RAW 264.7 cells through regulation of MAPK signaling pathway. Korean J. Plant Res. 34(1):23-30. https://doi.org/10.7732/KJPR.2021.34.1.023
  15. Kim, H.Y., S.Y. Nam, S.Y. Hwang, H.M. Kim and H.J. Jeong. 2016. Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models. Mol. Immunol. 78:121-132. https://doi.org/10.1016/j.molimm.2016.09.007
  16. Kim, S.J., M.C. Kim, J.Y. Um and S.H. Hong. 2010. The beneficial effect of vanillic acid on ulcerative colitis. Molecules 15:7208-7217. https://doi.org/10.3390/molecules15107208
  17. Kimur, J and N. Maki. 2002. New loliolide derivatives from the brown alga Undaria pinnatifida. J. Nat. Prod. 65:57-58. https://doi.org/10.1021/np0103057
  18. Lee, H.H., Y Cho, G.H. Kim and H. Cho. 2020. Undaria pinnatifida Fucoidan-Rich extract recovers immunity of immunosuppressed mice. J. Microbiol. Biotechnol. 30:439-447. https://doi.org/10.4014/jmb.1908.08026
  19. Martin, R.A., J.L. Ather, L.K. Lundblad, B.T. Suratt, J.E. Boyson, R.C. Budd, J.F. Alcorn, R.A. Flavell, S.C. Eisenbarth and M.E. Poynter. 2013. Interleukin-1 receptor and caspase-1 are required for the Th17 response in nitrogen dioxide-promoted allergic airway disease. Am. J. Respir. Cell Mol. Biol. 48:655-664. https://doi.org/10.1165/rcmb.2012-0423OC
  20. Modena, B.D., K. Dazy and A.A. White. 2016. Emerging concepts: Mast cell involvement in allergic diseases. Transl. Res. 174:98-121. https://doi.org/10.1016/j.trsl.2016.02.011
  21. Nam, S.Y, K.Y. Kim, M. H. Kim, J.B. Jang, S.Y. Rah, J.M. Lee, H.M. Kim and H.J. Jeong. 2017. Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan. Pharm. Biol. 55:1856-1862. https://doi.org/10.1080/13880209.2017.1339282
  22. Nam, S.Y., H.A. Oh, Y.G. Choi, K.Y. Park, H.M. Kim and H.J. Jeong. 2014. Inhibition of IL-32 Signaling by Bamboo Salt Decreases Pro-Inflammatory Responses in Cellular Models of Allergic Rhinitis. J. Med. Food. 17: 939-948. https://doi.org/10.1089/jmf.2013.2996
  23. Ogata, H and T. Hibi. 2003. Cytokine and anti-cytokine therapies for inflammatory bowel disease. Curr. Pharm. Des. 9:1107- 1113. https://doi.org/10.2174/1381612033455035
  24. Olivera, A., M.A. Beaven and D.D. Metcalfe. 2018. Mast cells signal their importance in health and disease. J. Allergy. Clin. Immunol. 142:381-393. https://doi.org/10.1016/j.jaci.2018.01.034
  25. Sakamoto, T., W. Ohashi, K. Tomita, K. Hattori, N. Matsuda and Y. Hattori. 2018. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-kappaB from the Toll-like receptor signaling pathways. Int Immunopharmacol. 62:120-131. https://doi.org/10.1016/j.intimp.2018.06.021
  26. Tak, P.P. and G.S. Firestein. 2001. NF-κB: A key role in inflammatory disease. J. Clin. Invest. 107:7-11. https://doi.org/10.1172/JCI11830
  27. Trefzer, U., M. Hofmann, W. Sterry and K. Asadullah. 2003. Cytokine and anti-cytokine therapy in dermatology. Expert Opin. Biol. Ther. 3:733-743. https://doi.org/10.1517/14712598.3.5.733
  28. Yao, C and S. Narumiya. 2019. Prostaglandin-cytokine crosstalk in chronic inflammation. Br. J. Pharmacol. 176(3):337-354. https://doi.org/10.1111/bph.14530
  29. Yoshinaga, K. and R. Mitamura. 2019. Effects of Undaria pinnatifida (Wakame) on postprandial glycemia and Insulin Levels in Humans: a Randomized Crossover Trial. Plant Foods Hum Nutr. 74(4):461-467. https://doi.org/10.1007/s11130-019-00763-5
  30. Yu, H.J., N.G. Geum, J.H. Ye and J.B. Jeong. 2021. Immuno-enhancing and anti-obesity effect of Abelmoschus manihot root extracts. Korean J. Plant Res. 34:411-419. https://doi.org/10.7732/KJPR.2021.34.5.411