Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Undaria pinnatifida Inhibits the Mast Cell-Mediated Inflammatory Response via NF-κB/Caspase-1 Suppression

  • Jeon, Yong-Deok (Department of Korean Pharmacy, Woosuk University) ;
  • Lee, Su-Hyun (Department of Biotechnology and Convergence, Daegu Haany University) ;
  • Kim, Su-Jin (Department of Biotechnology and Convergence, Daegu Haany University)
  • Received : 2021.11.12
  • Accepted : 2021.11.26
  • Published : 2021.12.01
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Abstract

Marine sources as potential treatment options for various diseases have been a subject of growing interest. However, information on the anti-inflammatory mechanism employed by Undaria pinnatifida (UP) remains limited. The present study was conducted to investigate the mechanisms of UP on the mast cell-mediated inflammatory response. To determine the pharmacological mechanism of UP in inflammatory reaction, we evaluated the effects of UP on interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α production and nuclear factor-κB (NF-κB) and caspase-1 activation in calcium ionophore A23187 plus phorbol 12-myristate 13-acetate-stimulated human mast cells-1 (HMC-1). The results showed that UP suppressed IL-6, IL-8 and TNF-α production in a dose-dependent manner. Moreover, UP significantly attenuated NF-kB/caspase-1 activation in stimulated HMC-1. Collectively, these findings provide experimental evidence that UP may be a useful candidate for the inflammation-related diseases treatment.

Keywords

Acknowledgement

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2021R1G1A1005944and NRF -2021R1F1A1047814).

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