Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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The Extract of Couroupita guianensis Aubl. Ameliorates Benign Prostatic Hyperplasia In Vitro and In Vivo

  • Kim, Yun Na (Department of Plant & Biomaterials Science, Gyeongsang National University) ;
  • Kim, Na-Hyun (Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology) ;
  • Souliya, Onevilay (Institute of Traditional Medicine, Ministry of Health) ;
  • Uddin, Salah (Ethnobotanical Database of Bangladesh) ;
  • Lee, Sang Woo (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Soo-Yong (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Choi, Sangho (International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Heo, Jeong-Doo (Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology) ;
  • Jeong, Eun Ju (Department of Plant & Biomaterials Science, Gyeongsang National University)
  • Received : 2021.11.20
  • Accepted : 2021.12.19
  • Published : 2021.12.31
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Abstract

The therapeutic effects of the leaves of Couroupita guianensis, a large tropical tree in the family of Lecythidaceae improving testosterone-induced Benign Prostatic Hyperplasia (BPH) were tested in vitro and in vivo. In BPH rats induced by castration and testosterone treatment, the prostate index was improved in groups administered with the extracts of C. guianensis extracted with 50%-, 100%-ethanol or boiling water, which was comparable with positive control, finasteride. The extract C. guianensis leaves showed significant inhibition on the expressions of type 2 5-alpha reductase (5αR) in RWPE-1 human prostatic epithelial cells, and effectively attenuated the expressions of androgen receptor, type 2 5αR and proliferating cell nuclear antigen in LNCap human prostatic adenocarcinoma cells. The leaves of C. guianensis that exerted evident suppression on BPH-related biomarkers in vitro and improvement of prostate index in vivo has a potential therapeutic use for the treatment of BPH.

Keywords

Acknowledgement

This work was supported by Gyeongsang National University Grant in 2020~2021.

References

  1. Roehrborn, C. G. Rev. Urol. 2005, 7, S3-S14.
  2. Tarter, T. H.; Vaughan Jr. E. D. Curr. Pharm. Des. 2006, 12, 775-783. https://doi.org/10.2174/138161206776056010
  3. Vahanwala, S. J.; Golatkar, S. G.; Rane, J. B.; Pawar, K. R.; Ambaye, R. Y.; Khadse, B. G. Indian Drugs 2000, 37, 343-345.
  4. Khan, M. R.; Kihara, M.; Omoloso, A. D. J. Herbs Spices Med. Plants 2003, 10, 95-108. https://doi.org/10.1300/J044v10n03_10
  5. Geetha, M.; Saluja, A. K.; Shankar, M. B.; Metha, R. S. J. Nat. Remedies 2004, 4, 52-55.
  6. Martinez, A.; Conde, E.; Moure, A.; Dominguez, H.; Estevez, R. J. Nat. Prod. Res. 2012, 26, 314-322. https://doi.org/10.1080/14786411003752094
  7. Anjaneyulu, A. S. R.; Rao, S. S. Indian J. Chem. Section B 1998, 37B, 382-386.
  8. Andrade, E. H. A.; Zoghbi, M. G. B.; Maia, J. G. S. J. Essent. Oil Res. 2000, 12, 163-166. https://doi.org/10.1080/10412905.2000.9699488
  9. Eknath, A. A.; Shivchandraji, L. K. Indian Drugs 2002, 39, 213-216.
  10. Prabhu, V.; Ravi, S. Int. J. Pharm. Pharm. Sci. 2012, 4, 126-130.
  11. Sarkar, P.; Zohora, F. T.; Jabbar, A.; Tareq, F. S.; Hasan, C. M.; Ahsan, M. Asian J. Chem. 2013, 25, 4559-4562. https://doi.org/10.14233/ajchem.2013.14066
  12. Costa, F. L. P.; Fernandes, S. B. O.; Fingolo, C. E.; Boylan, F.; Mota, G. V. S.; J. Comput. Theor. Nanosci. 2017, 14, 2383-2388. https://doi.org/10.1166/jctn.2017.6836
  13. Costa, D. C. M.; Azevedo, M. M. B.; Silva, D. O. E.; Romanos, M. T. V.; Souto-Padron, T. C. B. S.; Alviano, C. S.; Alviano, D. S. Nat. Prod. Res. 2017, 31, 2077-2080. https://doi.org/10.1080/14786419.2016.1272110
  14. Chuu, C. P.; Kokontis, J. M.; Hiipakka, R. A.; Fukuchi, J.; Lin, H. P.; Lin, C. Y.; Huo, C.; Su, L. C. J. Biomed. Sci. 2011, 18, 63. https://doi.org/10.1186/1423-0127-18-63
  15. Cunningham, D.; You, Z. J. Biol. Methods 2015, 2, e17. https://doi.org/10.14440/jbm.2015.63
  16. Nicholson, T. M.; Ricke, W. A. Differentiation 2011, 82, 184-199. https://doi.org/10.1016/j.diff.2011.04.006
  17. Bartsch, G.; Rittmaster, R. S.; Klocker, H. Eur. Urol. 2000, 37, 367-380. https://doi.org/10.1159/000020181
  18. Rittmaster, R. S. Best Pract. Res. Clin. Endocrinol. Metab. 2008, 22, 389-402. https://doi.org/10.1016/j.beem.2008.01.016
  19. Gelmann, E. P. J. Clin. Oncol. 2002, 20, 3001-3015. https://doi.org/10.1200/JCO.2002.10.018
  20. Traish, A. M.; Hassani, J.; Guay, A. T.; Zitzmann, M.; Hansen, M. L. J. Sex. Med. 2011, 8, 872-884. https://doi.org/10.1111/j.1743-6109.2010.02157.x
  21. Preuss, H. G.; Marcusen, C.; Regan, J.; Klimberg, I. W.; Welebir, T. A.; Jones, W. A. Int. Urol. Nephrol. 2001, 33, 217-225. https://doi.org/10.1023/A:1015227604041
  22. Rodriguez, C.; Patel, A. V.; Calle, E. E.; Jacobs, E. J.; Chao, A.; Thun, M. J. Cancer Epidemiol. Biomarkers Prev. 2001, 10, 345-353.