Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
권호 표지
DOI QR코드

DOI QR Code

No Time to Die, Born to Be Killers: Survival Is Accompanied by Exhaustion after an Endless Battle

  • Diederich, Sarah (BK21 Four Program, College of Pharmacy, Seoul National University) ;
  • Chung, Yeonseok (BK21 Four Program, College of Pharmacy, Seoul National University)
  • Received : 2021.11.11
  • Accepted : 2021.11.25
  • Published : 2021.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Keywords

Acknowledgement

This work was supported by the research grants: Global Research Laboratory Program (2017K1A1A2004511 [Y.C.]). The paper was written during an internship (S.D.) at the College of Pharmacy of the Seoul National University as a part of the master's program "Molecular and Cellular Biology" of the University of Munich.

References

  1. Abdel-Hakeem, M.S., Manne, S., Beltra, J.C., Stelekati, E., Chen, Z., Nzingha, K., Ali, M.A., Johnson, J.L., Giles, J.R., Mathew, D., et al. (2021). Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation. Nat. Immunol. 22, 1008-1019. https://doi.org/10.1038/s41590-021-00975-5
  2. Alfei, F., Kanev, K., Hofmann, M., Wu, M., Ghoneim, H.E., Roelli, P., Utzschneider, D.T., von Hoesslin, M., Cullen, J.G., Fan, Y., et al. (2019). TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection. Nature 571, 265-269. https://doi.org/10.1038/s41586-019-1326-9
  3. Beltra, J.C., Manne, S., Abdel-Hakeem, M.S., Kurachi, M., Giles, J.R., Chen, Z., Casella, V., Ngiow, S.F., Khan, O., Huang, Y.J., et al. (2020). Developmental relationships of four exhausted CD8(+) T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms. Immunity 52, 825-841.e8. https://doi.org/10.1016/j.immuni.2020.04.014
  4. Khan, O., Giles, J.R., McDonald, S., Manne, S., Ngiow, S.F., Patel, K.P., Werner, M.T., Huang, A.C., Alexander, K.A., Wu, J.E., et al. (2019). TOX transcriptionally and epigenetically programs CD8(+) T cell exhaustion. Nature 571, 211-218. https://doi.org/10.1038/s41586-019-1325-x
  5. Kim, B.S., Kuen, D.S., Koh, C.H., Kim, H.D., Chang, S.H., Kim, S., Jeon, Y.K., Park, Y.J., Choi, G., Kim, J., et al. (2021). Type 17 immunity promotes the exhaustion of CD8(+) T cells in cancer. J. Immunother. Cancer 9, e002603. https://doi.org/10.1136/jitc-2021-002603
  6. Yao, C., Sun, H.W., Lacey, N.E., Ji, Y., Moseman, E.A., Shih, H.Y., Heuston, E.F., Kirby, M., Anderson, S., Cheng, J., et al. (2019). Single-cell RNA-seq reveals TOX as a key regulator of CD8(+) T cell persistence in chronic infection. Nat. Immunol. 20, 890-901. https://doi.org/10.1038/s41590-019-0403-4