Journal of Korean Neurosurgical Society

  • 제64권2호
  • /
  • Pages.309-315
  • /
  • 2021
  • /
  • 2005-3711(pISSN)
  • /
  • 1598-7876(eISSN)
대한신경외과학회 (The Korean Neurosurgical Society)
권호 표지
DOI QR코드

DOI QR Code

Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population

  • Yang, Xitong (Genetic Testing Center, The First Affiliated hospital of Dali University) ;
  • Xu, Hongyang (Deparment of Encephalopathy, Hospital of Traditional Chinese Medicine) ;
  • Liu, Dan (Genetic Testing Center, The First Affiliated hospital of Dali University) ;
  • Ma, Rong (Genetic Testing Center, The First Affiliated hospital of Dali University) ;
  • Zhang, Yuanyuan (Genetic Testing Center, The First Affiliated hospital of Dali University) ;
  • Wang, Guangming (Genetic Testing Center, The First Affiliated hospital of Dali University)
  • 투고 : 2020.02.12
  • 심사 : 2020.04.14
  • 발행 : 2021.03.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective : To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region. Methods : This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed. Results : In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited no significant difference between the two groups. Conclusion : An association between rs723296 and the risk of IS was found in the Chinese Han population in Dali region. No significant association was found between rs1060499865, rs957960 and IS in the Chinese Han population in Dali region.

키워드

과제정보

This study was supported by the National Natural Science Foundation of China (No. 81360206); Reserve Talents of Academic and Technical Leaders of Young and Middle-aged People in Yunnan Province (No. 2014HB025); Scientific research fund project of Yunnan education department (2019J0775); and Colleges joint specific project in Yunnan Province (2019FH001-(020)).

참고문헌

  1. Baird AE : Genetics and genomics of stroke: novel approaches. J Am Coll Cardiol 56 : 245-253, 2010 https://doi.org/10.1016/j.jacc.2010.02.051
  2. Cao Q, Rong S, Repa JJ, Clair RS, Parks JS, Mishra N : Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development. Arterioscler Thromb Vasc Biol 34 : 1871-1879, 2014 https://doi.org/10.1161/ATVBAHA.114.303393
  3. Chinese Society of Neurology : The diagnosis of cerebrovascular diseases. CHN of J Neurol 29 : 379-380, 1996
  4. Ferronato S, Mombello A, Posenato I, Candiani P, Scuro A, Setacci C, et al. : Expression of circulating miR-17-92 cluster and HDAC9 gene in atherosclerotic patients with unstable and stable carotid plaques. Genet Test Mol Biomarkers 21 : 402-405, 2017 https://doi.org/10.1089/gtmb.2016.0384
  5. Han X, Han X, Wang Z, Shen J, Dong Q : HDAC9 regulates ox-LDL-induced endothelial cell apoptosis by participating in inflammatory reactions. Front Biosci (Landmark Ed) 21 : 907-917, 2016 https://doi.org/10.2741/4428
  6. Han Y, Sun W, Wang L, Tao S, Tian L, Hao Y, et al. : HDAC9 gene is associated with stroke risk in a Chinese population. Exp Biol Med (Maywood) 238 : 842-847, 2013 https://doi.org/10.1177/1535370213494650
  7. He M : The role and mechanism of acetylation epigenetic regulation molecule HDAC4/5 in ischemic brain injury. Jinan : Shandong University, 2012
  8. International Stroke Genetics Consortium (ISGC); Wellcome Trust Case Control Consortium 2 (WTCCC2), Bellenguez C, Bevan S, Gschwendtner A, Spencer CC, et al. : Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet 44 : 328-333, 2012 https://doi.org/10.1038/ng.1081
  9. Kalkonde YV, Sahane V, Deshmukh MD, Nila S, Mandava P, Bang A : High prevalence of stroke in Rural Gadchiroli, India: a community-based Study. Neuroepidemiology 46 : 235-239, 2016 https://doi.org/10.1159/000444487
  10. Kaluza D, Kroll J, Gesierich S, Manavski Y, Boeckel JN, Doebele C, et al. : Histone deacetylase 9 promotes angiogenesis by targeting the anti-angiogenic microRNA-17-92 cluster in endothelial cells. Arterioscler Thromb Vasc Biol 33 : 533-543, 2013 https://doi.org/10.1161/ATVBAHA.112.300415
  11. Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, et al. : Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci U S A 104 : 17335-17340, 2007 https://doi.org/10.1073/pnas.0706487104
  12. Liu WL, Lin YJ, Tao J, Peng J, Li GP, Chen LD, et al. : Study on the correlation between HDAC9 gene SNPs and large vessel atherosclerosis-induced ischemic stroke. Chin J Stroke 11 : 269-276, 2016
  13. Lu S, Li H, Li K, Fan XD : HDAC9 promotes brain ischemic injury by provoking lκBα/NF-κB and MAPKs signaling pathways. Biochem Biophys Res Commun 503 : 1322-1329, 2018 https://doi.org/10.1016/j.bbrc.2018.07.043
  14. Markus HS, Makela KM, Bevan S, Raitoharju E, Oksala N, Bis JC, et al. : Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis. Stroke 44 : 1220-1225, 2013 https://doi.org/10.1161/STROKEAHA.111.000217
  15. Musunuru K, Hickey KT, Al-Khatib SM, Delles C, Fornage M, Fox CS, et al. : Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association. Circ Cardiovasc Genet 8 : 216-242, 2015 https://doi.org/10.1161/HCG.0000000000000020
  16. Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, et al. : The histone deacetylase 9 gene encodes multiple protein isoforms. J Biol Chem 278 : 16059-16072, 2003 https://doi.org/10.1074/jbc.M212935200
  17. Prestel M, Prell-Schicker C, Webb T, Malik R, Lindner B, Ziesch N, et al. : The atherosclerosis risk variant rs2107595 mediates allele-specific transcriptional regulation of HDAC9 via E2F3 and Rb1. Stroke 50 : 2651-2660, 2019 https://doi.org/10.1161/STROKEAHA.119.026112
  18. Qingxu G, Yan Z, Jiannan X, Yunlong L : Association between the gene polymorphisms of HDAC9 and the risk of atherosclerosis and ischemic stroke. Pathol Oncol Res 22 : 103-107, 2016 https://doi.org/10.1007/s12253-015-9978-8
  19. Qingxu G, Yan Z, Jiannan X, Yunlong L : Association between the gene polymorphisms of HDAC9 and the risk of atherosclerosis and ischemic stroke. Pathol Oncol Res 22 : 103-107, 2016 https://doi.org/10.1007/s12253-015-9978-8
  20. Smith JD : New role for histone deacetylase 9 in atherosclerosis and inflammation. Arterioscler Thromb Vasc Biol 34 : 1798-1799, 2014 https://doi.org/10.1161/ATVBAHA.114.304295
  21. Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, et al. : Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 11 : 951-962, 2012 https://doi.org/10.1016/S1474-4422(12)70234-X
  22. Venketasubramanian N, Yoon BW, Pandian J, Navarro JC : Stroke epidemiology in South, East, and South-East Asia: a review. J Stroke 19 : 286-294, 2017 https://doi.org/10.5853/jos.2017.00234
  23. Wang M, Gu M, Li Z, Sun B, Cheng X, Dai Z, et al. : HDAC9 polymorphisms predict susceptibility, severity, and short-term outcome of large artery atherosclerotic stroke in Chinese population. J Mol Neurosci 67 : 165-171, 2019 https://doi.org/10.1007/s12031-018-1221-0
  24. Wang X, Sun Z, Zhang Y, Tian X, Li Q, Luo J : Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population. Neurol Res 39 : 351-356, 2017 https://doi.org/10.1080/01616412.2017.1289309
  25. Wang XB, Han YD, Sabina S, Cui NH, Zhang S, Liu ZJ, et al. : HDAC9 variant Rs2107595 modifies susceptibility to coronary artery disease and the severity of coronary atherosclerosis in a Chinese Han population. PLoS One 11 : e0160449, 2016 https://doi.org/10.1371/journal.pone.0160449
  26. Xu YL, Hu YY, Li JW, Zhou L, Li L, Niu YM : Aldehyde dehydrogenase 2 rs671G>A polymorphism and ischemic stroke risk in Chinese population: a meta-analysis. Neuropsychiatr Dis Treat 15 : 1015-1029, 2019 https://doi.org/10.2147/ndt.s196175
  27. Yeo BPH, Foong LC, Tam SM, Lee V, Hwang SS : Gene isolation using degenerate primers targeting protein motif: a laboratory exercise. Biochem Mol Biol Educ 46 : 47-53, 2018 https://doi.org/10.1002/bmb.21089
  28. Zhou M, Wang H, Zhu J, Chen W, Wang L, Liu S, et al. : Cause-specific mortality for 240 causes in China during 1990-2013: a systematic sub-national analysis for the Global Burden of Disease Study 2013. Lancet 387 : 251-272, 2016 https://doi.org/10.1016/S0140-6736(15)00551-6
  29. Zhu QB, Wu GM, Li GM, et al. : Study on the relationship between single nucleotides polymorphism rs2240419 of HDAC9 gene and the susceptibility to ischemic stroke and TCM syndromes in Guangdong Han population. Chinese Journal for Clinicians 47 : 35-40, 2019
  30. Zhu R, Liu X, He Z, Li Q : MiR-146a and miR-196a2 polymorphisms in patients with ischemic stroke in the northern Chinese Han population. Neurochem Res 39 : 1709-1716, 2014 https://doi.org/10.1007/s11064-014-1364-5