Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Polysomnography Analysis of Electroencephalography in Patients Expending Benzodiazepine Drugs

Benzodiazepine 계열 약물 복용 환자의 수면다원검사에서 도출된 EEG유형 분석

  • Jang, Da Jun (Department of Biomedical Laboratory Science, General Graduate School, Dankook University) ;
  • Lim, Dong Kyu (Department of Medical Laser, Dankook University Graduate School of Medicine) ;
  • Kim, Jae Kyung (Department of Biomedical Laboratory Science, Dankook University College of Health Sciences)
  • 장다준 (단국대학교 일반대학원 임상병리학과) ;
  • 임동규 (단국대학교 의학대학원 의학레이저협동과정) ;
  • 김재경 (단국대학교 보건과학대학 임상병리학과)
  • Received : 2021.10.29
  • Accepted : 2021.11.14
  • Published : 2021.12.31
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Abstract

Benzodiazepines (BDZs) drugs act on the GABAA receptor, function as nerve suppressors, and are used to treat anxiety, insomnia, and panic disorder. We analyzed the data of 30 individuals to determine any differences in the sleep-electroencephalogram findings among individuals varying in age, benzodiazepine use, and duration of benzodiazepine use. Comparisons between users and non-users of benzodiazepines, short-term and long-term users, older and younger users, and older short-term and older long-term users, were achieved using electroencephalographic findings obtained through polysomnography. The parameters evaluated included sleep latency, sleep efficiency, sleep-stage percentages, number of sleep spindles, and average frequency of sleep-spindle. The difference between benzodiazepine users and non-users was significant with respect to sleep-stage percentages and average frequency of sleep-spindle. Older and younger users differed significantly with respect to sleep efficiency and sleep-stage percentages, whereas significant difference for sleep efficiency was obtained between long-term and short-term users. Taken together, our results indicate that BDZ consumption suppresses slow-wave sleep and increases the frequency of sleep spindles.

벤조디아제핀은 GABAA 수용체에 작용하고 신경 억제제로 작용하며 불안, 불면증 및 공황 장애를 치료하는 데 사용되는 약물 그룹이다. 우리는 연령, 벤조디아제핀 사용 여부 및 사용 기간에 따라 수면 중 뇌파 소견에 차이가 있는지 관찰하기 위해 30명의 개인의 데이터를 분석했다. 수면다원검사를 통해 얻은 뇌파 소견을 이용하여 벤조디아제핀 복용군과 비복용군, 단기 및 장기복용, 노인과 비 노인군, 고령 단기복용 및 고령 장기복용군을 비교했다. 평가된 항목은 수면 잠복기, 수면 효율, 수면 단계별 백분율, sleep spindle의 개수 및 평균 주파수로 설정하였다. 복용군과 비복용군의 비교에서 sleep stage와 sleep spindle의 평균 주파수 항목에서 유의미하였다. 장기복용과 단기복용군의 비교에서 sleep efficiency 항목에서 유의미하였다. 노인군과 비 노인군과의 비교에서 sleep efficiency, sleep stage 항목에서 유의미하였다. 전반적으로 이 연구 결과를 바탕으로 벤조디아제핀의 사용은 느린 주파수 수면을 억제하고 수면 방추파의 주파수와 빈도를 증가시킨다는 결론을 내릴 수 있다.

Keywords

Acknowledgement

This article is article is based on a part of the first author's master's thesis from University.

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