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Anti-Obesity Effects of Red Beet Extract

  • Song, Hwan (Department of Beauty Design, Chodang University)
  • Received : 2021.11.27
  • Accepted : 2021.12.02
  • Published : 2021.12.31

Abstract

Obesity is caused by the accumulation of triglycerides in adipocytes by the differentiation and lipid synthesis process of pre-adipocytes, and excessive accumulation of adipocytes by the activated Adipogenesis process within the differentiated cells. Therefore, inhibiting the differentiation of adipocyte cells or controlling the adipogenesis process is known as an effective treatment method for obesity. This study evaluates the inhibition of Red beet root extract on pancreatic lipase and pre-adipocyte cell differentiation. Also it evaluates the Red beet root extract activities on C/EBP-𝛼,𝛽, and PPAR-𝛄. The experiments proved that the Red beet root extract inhibits pancreatic lipase by concentration dependency. Further, in 3T3-L1 inhabitation experiment, it was found Red beet root extract inhibited adipocyte formation. Red beet root extract also inhibits the expression of C/EBP-𝛼, C/EBP-𝛽, and PPAR-𝛾 which effect the process of adipocytic differentiation. We therefore concluded that RBE has a high potential to further studies on anti-obesity effect.

Keywords

References

  1. W. C. Willett, H. W. Dietz and G. A. Colditz, "Guidelines for healthy weight," New England Journal of Medicine, Vol. 341, pp. 427-432, Sep. 1999. DOI: https://doi.org/10.1056/NEJM199908053410607
  2. J. W. Chon, J. H. Sung, E. J. Hwang and Y. K Park, "Chlorella methanol extract reduces lipid accumulation in and increases the number of apoptotic 3T3-L1 cells," Annals of the New York Academy of Sciences, Vol. 1171, pp. 183-189, Aug. 2009. DOI : https://doi.org/10.1111/j.1749-6632.2009.04895.x
  3. T. Jeon, S. G. Hwang, S. Hirai, T. Matsui, H. Yano, T. Kawada, B. O. Lim and D. K Park, "Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells," Life Science, Vol. 75, No.26, pp. 3195-3203, Nov. 2004. DOI : https://doi.org/10.1016/j.lfs.2004.06.012
  4. J. G. Kang and C. Y. Park, "Anti-obesity drugs: A review about their effects and safety," Diabetes & Metabolish Journal, Vol. 36, No.1, pp. 13-25, Feb. 2012. DOI : https://doi.org/10.4093/dmj.2012.36.1.13
  5. K. S. Kim and S. W. Park, "Drug Therapy for obesity," Journal of Obesity & Metabolic Syndrome, Vol. 21, No. 4, pp. 197-202, Dec. 2012. DOI: https://doi.org/10.7570/kjo.2012.21.4.197
  6. J. A. Park, K. S. Jin, H. J. Kwon, and B. W. Kim, "The Anti-Obesity Effect of Smilax china Extract," Korean J. Microbiol. Biotechnol. Vol. 42, No. 4, pp. 354-360. Sep. 2014. DOI : http://dx.doi.org/10.4014/kjmb.1407.07009
  7. H. O. Boo, S. J. Hwang, C. S. Bae, S. H. Park and W. S. Song, "Antioxidant activity according to each kind of natural plant pigments," Korean Journal of Plant Resources, Vol.24, No. 1, pp. 105-112, Feb. 2011. DOI: https://doi.org/10.7732/kjpr.2011.24.1.105
  8. A. Pavlov, P. Kovatcheva , D. Tuneva, M. Ilieva and T. Bley, "Radical scavenging activity and stability of betalains from Beta vulgaris hairy root culture in simulated conditions of human gastrointestinal tract," Plant Food Human Nutrition, Vol. 60, pp. 43-47, Jun. 2005. DOI: https://doi.org/10.1007/s11130-005-5098-z
  9. C. H. Lee, M. Wettasinghe, B. W. Bolling, L. L. Ji and K. L. Parkin, "Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts," Nutrition and Cancer, Vol. 53 No. 1, pp. 91-103, Nov. 2009. DOI: https://doi.org/10.1207/s15327914nc5301_11
  10. A. Gliszczynska-Swiglo, H. Szymusiak and P. Malinowska, "Betanin, the main pigment of red beet: Molecular origin of its exceptionally high free radical-scavenging activity," Food Additives Contaminants, Vol. 23, No. 11, pp. 1079-1087, Feb. 2011. DOI: https://doi.org/10.1080/02652030600986032
  11. J. H. Lee and K. B. Chin, "Evaluation of antioxidant activities of red beet extracts, and physicochemical and microbial changes of ground pork patties containing red beet extracts during refrigerated storage," Food Science of Animal Resources, Vol. 32, No. 4, pp. 497- 503, Aug. 2012. DOI: https://doi.org/10.5851/kosfa.2012.32.4.497
  12. H. K. Kim, J. H. Lee, "Anti-cardiovascular Diseases Effects of Fermented Garlic and Fermented Chitosan," International Journal of Advanced Culture Technology. Vol. 6, No. 4. pp. 109-115. Nov. 2018. DOI https://doi.org/10.17703//IJACT2018.6.4.109
  13. J. S. Flier and F. E. Maratos, "Obesity and the hypothalamus: novel peptidesfor new pathways," A Cell Press Journal, Vol. 92, No. 4, pp. 437-440, Feb. 1998. DOI: https://doi.org/10.1016/S0092-8674(00)80937-X
  14. E. D. Rosen, P. Sarraf, A. E. Troy, G. Bradwin, K. Moore, D. S. Milstone, B. M. Spiegelman and R. M. Mortensen, "PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro," Molecular Cell, Vol. 4, No. 4, pp. 611-617, Oct. 1999. DOI: https://doi.org/10.1016/S1097-2765(00)80211-7
  15. M. H. Jang, X. L Piao, J. M. Kim, S. W. Kwon and J. H. Park, "Inhibition of cholinesterase and amyloid-beta aggregation by resveratrol oligomers from Vitis amurensis," Phytotherapy Research, Vol. 22, No. 4, pp. 544-549, Apr. 2008. DOI: https://doi.org/10.1002/ptr.2406
  16. L. Fajas, K. Schoonjans , L. Gelman, J. B. Kim, J. Najib, G. Martin, J. C. Fruchart, M. Briggs, B. M. Spiegelman and J. Auwerx, "Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Impli- cations for adipocyte differentiation and metabolism," Molecular and Cellular Biology, Vol. 19, No. 8, pp. 5495-5503, Dec. 2020 DOI: https://doi.org/10.1128/MCB.19.8.5495
  17. H. J. Kim, C. H. Kang and S. K. Kim, "Anti-adipogenic effect of Undaria pinnatifida extracts by ethanol in 3T3-L1 adipocytes," Journal of Life Science, Vol. 22, No. 8, pp. 1052-1056, Aug. 2012. DOI: https://doi.org/10.5352/JLS.2012.22.8.1052
  18. J. A. Park, C. Park, M. H. Han, B. W. Kim, Y. H. Chung and Y. H. Choi, "Inhibition of adipocyte differentiation and adipogenesis by aged black garlic extracts in 3T3-L1 preadipocytes," Journal of Life Science, Vol 21, No. 5, pp. 720-728. May 2011. DOI: https://doi.org/10.5352/JLS.2011.21.5.720