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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Remodeling of host glycoproteins during bacterial infection

  • Kim, Yeolhoe (Department of Systems Biology, BK21 Plus Project, College of Life Science and Biotechnology, Yonsei University) ;
  • Ko, Jeong Yeon (Department of Systems Biology, BK21 Plus Project, College of Life Science and Biotechnology, Yonsei University) ;
  • Yang, Won Ho (Department of Systems Biology, BK21 Plus Project, College of Life Science and Biotechnology, Yonsei University)
  • Received : 2021.08.20
  • Accepted : 2021.10.20
  • Published : 2021.11.30
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Abstract

Protein glycosylation is a common post-translational modification found in all living organisms. This modification in bacterial pathogens plays a pivotal role in their infectious processes including pathogenicity, immune evasion, and host-pathogen interactions. Importantly, many key proteins of host immune systems are also glycosylated and bacterial pathogens can notably modulate glycosylation of these host proteins to facilitate pathogenesis through the induction of abnormal host protein activity and abundance. In recent years, interest in studying the regulation of host protein glycosylation caused by bacterial pathogens is increasing to fully understand bacterial pathogenesis. In this review, we focus on how bacterial pathogens regulate remodeling of host glycoproteins during infections to promote the pathogenesis.

Keywords

Acknowledgement

This work was supported by the Yonsei Research Fund (2019-22-0020) and the National Research Foundation of Korea (NRF) Ministry of Science, ICT and Future Planning NRF-2016R1A5A1010764 and NRF-2020R1A2C101232911.

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