The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Anticancer and Immunomodulatory Effects of Formosa Plum Extracts on Non-small Cell Lung Carcinoma, NCI-H520, Xenograft Mice

비소세포 폐암 세포 (NCI-H520) 이식 마우스에서 포모사 자두 추출물의 면역활성 및 악액질 억제효과

  • Son, Young-Sook (Department of Herbology, College of Korea Medicine Daegu Haany University) ;
  • Lee, Sang-nam (Department of Qigong, College of Korea Medicine Daegu Haany University) ;
  • Park, Ji-Ha (Department of Herbology, College of Korea Medicine Daegu Haany University)
  • 손영숙 (대구한의대학교 한의과대학 본초학교실) ;
  • 이상남 (대구한의대학교 한의과대학 기공학교실) ;
  • 박지하 (대구한의대학교 한의과대학 본초학교실)
  • Received : 2020.11.12
  • Accepted : 2020.11.25
  • Published : 2020.11.30
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Abstract

Objectives : The object of this study was to observe anticancer and immunomodulatory effects of Formosa plum aqueous extracts (PLe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Method : Three different dosages of PLe, 50, 100 and 200 mg/kg were orally administered once a day for 28 days from 11 days after tumor cell inoculation. Five groups, each of seven mice per group were used in the present study as follows. Tumor volume and weights, serum interferon (IFN)-γ levels, serum IL-6 were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. Result : Although no meaningful changes on the tumor weights and volumes were observed after treatment of all three different dosages of PLe, decreases of tumor cell volumes in tumor masses were dose-dependently decreased mediated by increases of apoptosis among tumor cells by treatment of PLe 100 and 200 mg/kg as compared with tumor-bearing control. In addition, decreases on the body weight and gains were also demonstrated in tumor-bearing control with increases of serum IL-6 levels. Conclusion : The results obtained in this study suggest that over 50 mg/kg of PLe showed favorable immunomodulatory and anticachexic effects with anticancer effects in 100 and 200 mg/kg of PLe treated groups on the NCI-H520 cell xenograft. However, detail mechanism studies should be conducted in future with the screening of the biological active compounds in this herb.

Keywords

References

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