DOI QR코드

DOI QR Code

A Case Report of an Advanced Gastric Cancer Patient Who Was Able to Undergo Conversion Surgery Treated with Chemotherapy and Korean Medicine

항암화학요법과 한방치료를 병행하여 전환수술이 가능하게 호전된 진행성 위암 환자 1례

  • Jang, Kwon-jun (Jangdeuk Korean Medicine Hospital) ;
  • Ko, Eun-bi (Jangdeuk Korean Medicine Hospital) ;
  • Hwang, Woo-seok (Jangdeuk Korean Medicine Hospital) ;
  • Kim, Kwan-il (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Beom-joon (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University) ;
  • Jung, Hee-jae (Division of Allergy, Immune & Respiratory System, Dept. of Internal Medicine, Graduate School, Kyung Hee University) ;
  • Shin, Kwang-soon (Jangdeuk Korean Medicine Hospital)
  • 장권준 (장덕한방병원) ;
  • 고은비 (장덕한방병원) ;
  • 황우석 (장덕한방병원) ;
  • 김관일 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 이범준 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 정희재 (경희대학교대학원 임상한의학과 폐계내과학교실) ;
  • 신광순 (장덕한방병원)
  • Received : 2020.09.29
  • Accepted : 2020.10.26
  • Published : 2020.10.30

Abstract

Objectives: The purpose of this study was to report a case of a patient with advanced gastric cancer with peritoneal metastasis treated with chemotherapy and Korean medicine Methods: A patient with advanced gastric cancer with peritoneal metastasis was treated with Xeloda/cisplatin since April 2019. The cycle was repeated every three weeks for a total of 11 times. At the same time, the patient was treated with Korean medicine. The tumor size was measured by computed tomography (CT) and esophagogastroduodenoscopy (EGD). Adverse events were evaluated by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0. Results: After treatment with Xeloda/cisplatin and Korean medicine for nine months, the extent of the proximal portion of the primary tumor and the size and number of multiple nodules around the stomach decreased and the cancer cells with peritoneal metastasis disappeared. The symptoms of discomfort and physical activity were gradually improved. As a result, the patient underwent conversion surgery. Conclusions: This case study suggests that the combination of chemotherapy and Korean medicine may contribute to the reduction in tumor size as well as the improvement in the quality of life.

Keywords

References

  1. Gastric Cancer. National Cancer Information Center. Available from: URL: https://www.cancer.go.kr/. Published 2020. Accessed August 14, 2020.
  2. Katai H, Sano T. Early gastric cancer: concepts, diagnosis, and management. Int J Clin Oncol 2005;10(6):375-83. https://doi.org/10.1007/s10147-005-0534-5
  3. Ono H. Early gastric cancer: diagnosis, pathology, treatment techniques and treatment outcomes. Eur J Gastroenterol He-patol 2006;18(8):863-6. https://doi.org/10.1097/00042737-200608000-00009
  4. Gastric Cancer Treatment (PDQ(R))-Patient Version. National Cancer Institute. Available from: URL: https://www.cancer.gov/types/stomach/patient/stomach-treatment-pdq. Published 2020. Accessed August 14, 2020.
  5. Ministry of Health and Welfare. Cancer Registration Statistics-Statistical Information Report. 2019.
  6. Morgagni P, Solaini L, Framarini M, Vittimberga G, Gardini A, Tringali D, et al. Conversion surgery for gastric cancer: A cohort study from a western center. International journal of surgery 2018;53:360-5. https://doi.org/10.1016/j.ijsu.2018.04.016
  7. Chang SH, Park JH, Yoo HS. A Case Report of Partial Remission of Renal Cell Carcinoma with Multiple Liver Metastases Treated with Korean Herbal Medicine in Conjunction with Targeted Anticancer Therapy Afinitor. Journal of Korean traditional oncology 2017;22(2):13-24. https://doi.org/10.15432/JKTO.2017.22.2.013
  8. 이성재. 통합 의학적 암 치료. 식품기술 2007;20(3):154-61.
  9. Smith TJ, Temin S, Alesi ER, Abernethy AP, Balboni TA, Basch EM, et al. American Society of Clinical Oncology provisional clinical opinion: the integration of palliative care into standard oncology care. Journal of clinical oncology 2012;30(8):880-7. https://doi.org/10.1200/JCO.2011.38.5161
  10. National Comprehensive Cancer Network. NCCN Guidelines for Patients-Stomach Cancer. 2019.
  11. 김동희, 김성훈. 항암제(抗癌劑) 부작용(副作用)에 대한 한방요법(韓方療法). 대전대학교한의학 연구소 논문집 1993;2(1):33-51.
  12. Sohaib A. RECIST rules. Cancer Imaging 2012;12(2):345-6. https://doi.org/10.1102/1470-7330.2012.9011
  13. Watanabe H, Okada M, Kaji Y, Satouchi M, Sato Y, Yamabe Y, et al. [New Response Evaluation Criteria in Solid Tumours-Revised RECIST Guideline(version 1.1).]. Cancer & chemotherapy 2009;36(13):2495-501.
  14. Common Terminology Criteria for Adverse Events (CTCAE). National Cancer Institute.Available from: URL: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm. Published 2020. Accessed August 14, 2020.
  15. Jeung HC, Rha SY. Recent advance in tailored treatment of gastric cancer. The Korean journal of medicine 2009;77(1):1-8.
  16. Park JM, Ryu WS, Kim JH, Park SS, Kim SJ, Kim CS, et al. Prognostic factors for advanced gastric cancer: Stage-stratified analysis of patients who underwent curative resection. Cancer research and treatment 2006;38(1):13-8. https://doi.org/10.4143/crt.2006.38.1.13
  17. Korean Gastric Cancer Association. Gastric Cancer 2018: an Evidence-based, Multi-disciplinary Approach. Journal of Gastric Cancer 2019;19(1):1-48. https://doi.org/10.5230/jgc.2019.19.e8
  18. Kim HR, Yoo HS, Baek DG, Park IH, Jang CY, Kim HY, et al. Clinical Practice Guidelines in Korean Medicine for Gastric Cancer. The journal of internal Korean medicine 2016;37(1):26-46.
  19. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, et al. American College of Sports Medicine Roundtable on Exercise Guidelines for Cancer Survivors. Medicine and science in sports and exercise 2010;42(7):1409-26. https://doi.org/10.1249/MSS.0b013e3181e0c112
  20. Chen S, Flower A, Ritchie A, Liu J, Molassiotis A, Yu H, et al. Oral Chinese herbal medicine (CHM) as an adjuvant treatment during chemotherapy for non-small cell lung cancer: A systematic review. Lung cancer 2010;68(2):137-45. https://doi.org/10.1016/j.lungcan.2009.11.008
  21. 조종관. 면역에 관한 동양의학적 고찰. 동양의학 1986;12(1):19-23.
  22. 심범상, 최승훈. A Literatural Study on Pattern Identification Type of Stomach Cancer. Korean Journal of Oriental Physiology & Pathology 1993;8(1):295-303.
  23. Lee YW. A study on the regimen for Gastroenteric disease. Journal of Hawhwa Medicine 2008;17(2):1-15.
  24. Lee HY, Kang JS. Study on Physiological Character of Stomach, and Correlation of Stomach Qi(胃氣) and True Visceral Pulse(眞藏脈). J Oriental Medical Classics 2011;24(4):143-55.
  25. Lee DJ, Kim JH, Hwang UW. Experimental studies on anti-stress effects of Bohyulanshintang and Gamibohyulanshintang. Journal of oriental neuropsychiatry 1993;4(1):77-97.
  26. Lee SH, Lim SW. The Defensive Effect of Samooltang on Injury of Gastric Mucous Membrane of Mouse by Ethanol. Journal of Korean Oriental Medicine 2004;25(3):1-11.
  27. Lee HS, Lee HI, Park SI, Lee DY. Network Pharmacology-Based Investigation of the System-Level Molecular Mechanisms of the Hematopoietic Activity of Samul-Tang, a Traditional Korean Herbal Formula. Evidence-based Complementary and Alternative Medicine 2020.
  28. Jeong JS. Bojungikki-tang for cancer-related fatigue : a randomized, waiting list controlled trial. Department of Oriental Medicine Graduate School Kyung Hee University 2010:1-26.
  29. Kayo T, Suzuki M, Takeda T, Fukuda F, Ishizaki N, Kitakoji H, et al. Acupuncture for functional abdominal pain syndrome: a case report. Journal of the Japan society of acupuncture 2010;60(4):744-51.
  30. Wong R, Sagar S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy--a case series. Acupuncture in medicine : journal of the British Medical Acupuncture Society 2006;24(2):87-91. https://doi.org/10.1136/aim.24.2.87
  31. Lim SY, Lee SJ, Kwon KR. Anti-cancer and Immune Promoting Effects of Cultivated Wild Ginseng Herbal Acupuncture on Hepatic Metastatic Model Using Colon26-L5 Carcinoma Cells. The journal of Korean Acupuncture & Moxibustion Society 2006;23(1):121-34.
  32. Toriyama-Baba H, Ligo M, Asamoto M, Iwahori Y, Park CB, Han BS, et al. Organotropic Chemopreventive Effects of n- 3 Unsaturated Fatty Acids in a Rat Multi-organ Carcinogenesis Model. Jpn J Cancer Res 2001;92(11):1175-83. https://doi.org/10.1111/j.1349-7006.2001.tb02137.x
  33. Petrovich Z, Stanley K, Cox JD, Paig C. Radiotherapy in the management of locally advanced lung cancer of all cell types: final report of randomized trial. Cancer 1981;48(6):1135-40.
  34. Chen YM. Update of epidermal growth factor receptor-tyrosine kinase inhibitors in nonsmall-cell lung cancer. J Chin Med Assoc 2013;76(5):249-57. https://doi.org/10.1016/j.jcma.2013.01.010
  35. Boku T, Nakane Y, Minoura T, Takada H, Yamamura M, Hioki K, et al. Prognostic significance of serosal invasion and free intraperitoneal cancer cells in gastric cancer. British journal of surgery : BJS 1990;77(4):436-9. https://doi.org/10.1002/bjs.1800770425

Cited by

  1. 갑상선 유두암의 외과적 절제술 이후 발생한 후유증에 대한 면역요법을 병행한 한방 치험 3례 vol.42, pp.5, 2021, https://doi.org/10.22246/jikm.2021.42.5.746