The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Effect of intraperitoneally administered propentofylline in a rat model of postoperative pain

  • Choi, Geun Joo (Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine) ;
  • Kang, Hyun (Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine) ;
  • Lee, Jun Mo (Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine) ;
  • Baek, Chong Wha (Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine) ;
  • Jung, Yong Hun (Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine) ;
  • Woo, Young Cheol (Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine) ;
  • Do, Jae Hyuk (Department of Internal Medicine, Chung-Ang University College of Medicine) ;
  • Ko, Jin Soo (Department of Plastic Surgery, National Police Hospital)
  • Received : 2020.07.08
  • Accepted : 2020.08.09
  • Published : 2020.09.30
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Abstract

Background: In this study, we sought to evaluate whether systemic propentofylline (PPF) has antiallodynic effects in a rat model of postoperative pain, and to assess the mechanism involved. Methods: After plantar incision, rats were intraperitoneally injected with various doses of PPF to evaluate its antiallodynic effect. To investigate the involved mechanism, rats were intraperitoneally injected with yohimbine, dexmedetomidine, prazosin, naloxone, atropine or mecamylamine, following the incision of the rat hind paws, and then PPF was administered intraperitoneally. The mechanical withdrawal threshold (MWT) was evaluated using von Frey filaments at various time points and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 were measured to determine the inflammatory response level. Results: MWT was significantly increased after intraperitoneal injection of 30 mg/kg of PPF when compared with the control group. Injection of PPF and yohimbine, atropine or mecamylamine showed significant decreases in the MWT, while injection of PPF and dexmedetomidine showed a significant increase. Systemic administration of PPF inhibited the post-incisional increase in serum level of TNF-α and IL-1β. Conclusions: Systemic administration of PPF following surgery presented antiallodynic effects in a rat model of postoperative pain. The antiallodynic effects against mechanical allodynia could be mediated by α-adrenergic and cholinergic receptors.

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References

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