참고문헌
- J.A. Obeso, M.C. Rodriguez-Oroz, C.G. Goetz, C. Marin, J.H. Kordower, M.Rodriguez, E.C. Hirsch, M. Farrer, A.H. Schapira, G. Halliday, "Missing piecesin the Parkinson's disease puzzle", Nature Medicine, Vol.16, No.6 pp. 653-661, (2010). https://doi.org/10.1038/nm.2165
- L.V. Kalia,A.E. Lang, "Parkinson's disease", The Lancet, Vol.386, No.9996 pp. 896-912, (2015). https://doi.org/10.1016/S0140-6736(14)61393-3
- A.B. Singleton,M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T.Peuralinna, A. Dutra, R. Nussbaum, S. Lincoln, A. Crawley, M. Hanson, D.Maraganore, C. Adler, M.R. Cookson, M. Muenter, M. Baptista, D. Miller, J.Blancato, J. Hardy, K. Gwinn-Hardy, "alpha-Synuclein locus triplication causesParkinson's disease", Science, Vol.302, No5646 pp. 841, (2003). https://doi.org/10.1126/science.1090278
- S.W. Tait, D.R.Green, "Mitochondrial regulation of cell death", Cold Spring Harbor Perspectives in Biology, Vol.15, No.9 a008706, (2013).
-
C. Ciron, L.Zheng, W. Bobela, G.W. Knott, T.C. Leone, D.P. Kelly, B.L. Schneider, "PGC-
$1{\alpha}$ activity in nigral dopamine neurons determines vulnerability to$\alpha$ -synuclein", Acta Neuropathologica Communications, Vol.3, No.16 s40478-015-0200-8, (2015). - G.M. Petzinger,B.E. Fisher, S. McEwen, J.A. Beeler, J.P. Walsh, M.W. Jakowec, "Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease", The Lancet Neurology, Vol.12, No7 pp. 716-726, (2013). https://doi.org/10.1016/S1474-4422(13)70123-6
-
J.H. Koo, Y.C.Jang, D.J. Hwang, H.S. Um, N.H. Lee, J.H. Jung, J.Y. Cho, "Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-
${\kappa}B$ signaling pathway", Neuroscience, Vol.356, pp. 102-113, (2017). https://doi.org/10.1016/j.neuroscience.2017.05.016 - Y. Jang, J.H. Koo, I. Kwon, E.B. Kang, H.S. Um, H. Soya, Y. Lee, J.Y. Cho, "Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson's disease mice", Brain Research, Vol.1655, pp. 186-193, (2017). https://doi.org/10.1016/j.brainres.2016.10.029
- Y. Jang, I.Kwon, W. Song, L.M. Cosio-Lima, S. Taylor, Y. Lee, "Modulation of mitochondrial phenotypes by endurance exercise contributes to neuroprotection against a MPTP-induced animal model of PD", Life Science, Vol.209, pp. 455-465, (2018). https://doi.org/10.1016/j.lfs.2018.08.045
- A.O. Oyewole, M.A. Birch-Machin, "Mitochondria-targeted antioxidants", The FASEB Journal, Vol.29, No.12 pp. 4766-4771, (2015). https://doi.org/10.1096/fj.15-275404
- M.J. McManus, M.P. Murphy, J.L. Franklin, "The mitochondria-targeted antioxidant MitoQprevents loss of spatial memory retention and early neuropathology in atransgenic mouse model of Alzheimer's disease", Journal of Neuroscience, Vol.31, No.44 pp. 15703-15715, (2011). https://doi.org/10.1523/JNEUROSCI.0552-11.2011
- H. Jin, A. Kanthasamy, A. Ghosh, V. Anantharam, B. Kalyanaraman, A.G. Kanthasamy, "Mitochondria-targeted antioxidants for treatment of Parkinson's disease:preclinical and clinical outcomes", Biochimica et Biophysica Acta, Vol.1842, No.8 pp. 1282-1294, (2014). https://doi.org/10.1016/j.bbadis.2013.09.007
- B.J. Snow,F.L. Rolfe, M.M. Lockhart, C.M. Frampton, J.D. O'Sullivan, V. Fung, R.A. Smith,M.P. Murphy, K.M. Taylor, "A double-blind, placebo-controlled study to assessthe mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease", Movement Disorders, Vol.25, No.11 pp. 1670-1674, (2014). https://doi.org/10.1002/mds.23148
- Y.S. Lau, G. Patki, K. Das-Panja, W.D. Le, S.O. Ahmad, "Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson's disease with moderate neurodegeneration", European Journal of Neuroscience, Vol.33, No.7 pp. 1264-1274, (2011). https://doi.org/10.1111/j.1460-9568.2011.07626.x
- S.Rodriguez-Cuenca, H.M. Cocheme, A. Logan, I. Abakumova, T.A. Prime, C. Rose, A.Vidal-Puig, A.C. Smith, D.C. Rubinsztein, I.M. Fearnley, B.A. Jones, S. Pope,S.J. Heales, B.Y. Lam, S.G. Neogi, I. McFarlane, A.M. James, R.A. Smith, M.P.Murphy, "Consequences of long-term oral administration of the mitochondriatargeted antioxidant MitoQ to wild-type mice", Free Radical Biology & Medicine, Vol.48, No.1 pp. 161-72, (2010). https://doi.org/10.1016/j.freeradbiomed.2009.10.039
- M.M Bradford, "A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding", Analytical Biochemistry, Vol.72, No.1-2 pp. 248-254, (1976). https://doi.org/10.1016/0003-2697(76)90527-3
- G.E. Meredith,D.J. Rademacher, "MPTP mouse models of Parkinson's disease: an update", Journal of Parkinson's Disease, Vol.1, No.1 pp. 19-33, (2011). https://doi.org/10.3233/JPD-2011-11023
- G.M.Petzinger, J.P. Walsh, G. Akopian, E. Hogg, A. Abernathy, P. Arevalo, P.Turnquist, M. Vuckovic, B.E. Fisher, D.M. Togasaki, M.W. Jakowec, "Effects of treadmill exercise on dopaminergic transmission in the1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury", Journal of Neuroscience, Vol.27, No.20 pp. 5291- 5300, (2007). https://doi.org/10.1523/JNEUROSCI.1069-07.2007
- H.F. Shu, T.Yang, S.X. Yu, H.D. Huang, L.L. Jiang, J.W. Gu, Y.Q. Kuang, "Aerobic exercisefor Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials", PLoS One, Vol.9, No.7 pp. e100503, (2014). https://doi.org/10.1371/journal.pone.0100503
- H.S. Cho, M.S.Shin, W. Song, T.W. Jun, B.V. Lim, Y.P. Kim, C.J. Kim, "Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamineinduced Parkinson's rats", Journal of Exercise Rehabilitation, Vol.9, No.3 pp. 354-364, (2013). https://doi.org/10.12965/jer.130048
- A. Ghosh, K.Chandran, S.V. Kalivendi, J. Joseph, W.E. Antholine, C.J. Hillard, A.Kanthasamy, A. Kanthasamy, B. Kalyanaraman, Neuroprotection by amitochondria-targeted drug in a Parkinson's disease model, Free Radical Biology & Medicine, Vol.49, No.11 pp. 1674-1684, (2010). https://doi.org/10.1016/j.freeradbiomed.2010.08.028
- L. Xu, J. Pu, "Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application", Parkinson's Disease, Vol.2016, 1720621, (2016).
-
W. Zhou, J.C.Barkow, C.R. Freed, "Running wheel exercise reduces
$\alpha$ -synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease", PLoS One, Vol.12, No.12 e0190160, (2017). https://doi.org/10.1371/journal.pone.0190160 - L. Yang, N.Y.Calingasan, E.J. Wille, K. Cormier, K. Smith, R.J. Ferrante, M.F. Beal, "Combination therapy with coenzyme Q10 and creatine produces additiveneuroprotective effects in models of Parkinson's and Huntington's diseases", Journal of Neurochemistry, Vol.105, No.5 pp. 1427-1439, (2009).
- M.R. Cookson, "Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways", Cold Spring Harbor Perspectives in Medicine, Vol.2, No.9 a009415, (2012). https://doi.org/10.1101/cshperspect.a009415
- J.H. Park,J.D. Burgess, A.H. Faroqi, N.N. DeMeo, F.C. Fiesel, W. Springer, M. Delenclos, P.J. McLean, "Alpha-synucleininduced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway", Molecular Neurodegeneration, Vol.15, No.1 s13024-019-0349, (2020).
-
J.H. Koo, J.Y.Cho, "Treadmill Exercise Attenuates
$\alpha$ -Synuclein Levels by Promoting Mitochondrial Function and Autophagy Possibly via SIRT1 in the Chronic MPTP/P-Induced Mouse Model of Parkinson's Disease", Neurotoxicity Research, Vol.32, No.3 pp. 473-486, (2017). https://doi.org/10.1007/s12640-017-9770-5 -
Y. Xi, D.Feng, K. Tao, R. Wang, Y. Shi, H. Qin, M.P. Murphy, Q. Yang, G. Zhao, "MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-
$1{\alpha}$ ", Biochimica et Biophysica Acta-Molecular Basis of Disease, Vol.2864, No.9 pp. 2859-2870, (2018). - Y.C. Jang ,D.J. Hwang, J.H. Koo, H.S. Um, N.H. Lee, D.C. Yeom, Y. Lee, J.Y. Cho, "Association of exercise-induced autophagy upregulation and apoptosiss uppression with neuroprotection against pharmacologically induced Parkinson's disease", J Exerc Nutrition Biochem, Vol.22, No.1 pp. 1-8, (2018). https://doi.org/10.20463/jenb.2018.0001